Functional characterisation of a SNP in the ABCC11 allele - effects on axillary skin metabolism, odour generation and associated behaviours
| Autor: | Sally G. Grimshaw, Sheila Gonzales-Tanon, Gertrude P. Chan, David S. Arnold, Ann-Marie Carvell, Egge Aart Eddy Rosing, Hailey Kelso, Jane Shaw, Zee M. Alcasid, Adrian M. Smith, Svetlana Riazanskaia, Mark Harker, Jayne Kirk, Vernon P.J. Marti, David Taylor, Rüdiger Zillmer |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Health Knowledge Attitudes Practice Heterozygote Adolescent Metabolite Health Behavior Physiology Single-nucleotide polymorphism Dermatology Biochemistry Polymorphism Single Nucleotide chemistry.chemical_compound Young Adult Personal hygiene Gene Frequency parasitic diseases Genotype medicine SNP Humans Allele ABCC11 Molecular Biology Skin biology Deodorants fungi Homozygote Metabolism Awareness Skin Care Apocrine Glands Phenotype chemistry Axilla Odorants behavior and behavior mechanisms biology.protein ATP-Binding Cassette Transporters Female psychological phenomena and processes |
| Zdroj: | Journal of dermatological science. 73(1) |
| ISSN: | 1873-569X |
| Popis: | Background A single nucleotide polymorphism (SNP), 538G→A, leading to a G180R substitution in the ABCC11 gene results in reduced concentrations of apocrine derived axillary odour precursors. Objective Determine the axillary odour levels in the SNP ABCC11 genotype variants and to investigate if other parameters associated with odour production are affected. Methods Axillary odour was assessed by subjective quantification and gas chromatography headspace analysis. Metabolite profiles, microbiome diversity and personal hygiene habits were also assessed. Results Axillary odour in the A/A homozygotes was significantly lower compared to the G/A and G/G genotypes. However, the perception-based measures still detected appreciable levels of axillary odour in the A/A subjects. Metabolomic analysis highlighted significant differences in axillary skin metabolites between A/A subjects compared to those carrying the G allele. These differences resulted in A/A subjects lacking specific volatile odourants in the axillary headspace, but all genotypes produced odoriferous short chain fatty acids. Microbiomic analysis revealed differences in the relative abundance of key bacterial genera associated with odour generation between the different genotypes. Deodorant usage indicated a high level of self awareness of axillary odour levels with A/A individuals less likely to adopt personal hygiene habits designed to eradicate/mask its presence. Conclusions The SNP in the ABCC11 gene results in lower levels of axillary odour in the A/A homozygotes compared to those carrying the G allele, but A/A subjects still produce noticeable amounts of axillary odour. Differences in axillary skin metabolites, bacterial genera and personal hygiene behaviours also appear to be influenced by this SNP. |
| Databáze: | OpenAIRE |
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