Meningitis, meningoencephalitis and encephalitis in Bern: an observational study of 258 patients
| Autor: | Anamaria Ungureanu, C. Bassetti, Léonore Jaques, Franziska Suter-Riniker, Julia van der Meer, Stephen L. Leib, Gabriele Chiffi, Antonela Bicvic, Anelia Dietmann, Lena S Abbuehl |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Pediatrics
medicine.medical_specialty 610 Medicine & health Communicable Diseases Meningitis Bacterial Meningoencephalitis Tick-borne encephalitis medicine Humans Meningitis RC346-429 Sleep-wake disturbances Retrospective Studies business.industry General Medicine medicine.disease 570 Life sciences biology Encephalitis Observational study Neurology (clinical) Neurology. Diseases of the nervous system business Research Article |
| Zdroj: | BMC Neurology, Vol 21, Iss 1, Pp 1-11 (2021) BMC Neurology Ungureanu, Anamaria; van der Meer, Julia; Bicvic, Antonela; Abbuehl, Lena; Chiffi, Gabriele; Jaques, Léonore; Suter-Riniker, Franziska; Leib, Stephen L.; Bassetti, Claudio L.A.; Dietmann, Anelia (2021). Meningitis, meningoencephalitis and encephalitis in Bern: an observational study of 258 patients. BMC neurology, 21(1), p. 474. BioMed Central 10.1186/s12883-021-02502-3 |
| ISSN: | 1471-2377 |
| DOI: | 10.1186/s12883-021-02502-3 |
| Popis: | Background Depending on geographic location, causes of encephalitis, meningoencephalitis and meningitis vary substantially. We aimed to identify the most frequent causes, clinical presentation and long-term outcome of encephalitis, meningoencephalitis and meningitis cases treated in the Inselspital University Hospital Bern, Switzerland. Methods In this monocentric, observational study, we performed a retrospective review of clinical patient records for all patients treated within a 3-year period. Patients were contacted for a telephone follow-up interview and to fill out questionnaires, especially related to disturbances of sleep and wakefulness. Results We included 258 patients with the following conditions: encephalitis (18%), nonbacterial meningoencephalitis (42%), nonbacterial meningitis (27%) and bacterial meningoencephalitis/meningitis (13%). Herpes simplex virus (HSV) was the most common cause of encephalitis (18%); tick-borne encephalitis virus (TBEV) was the most common cause of nonbacterial meningoencephalitis (46%), enterovirus was the most common cause of nonbacterial meningitis (21%) and Streptococcus pneumoniae was the most common cause of bacterial meningoencephalitis/meningitis (49%). Overall, 35% patients remained without a known cause. After a median time of 16 months, 162 patients participated in the follow-up interview; 56% reported suffering from neurological long-term sequelae such as fatigue and/or excessive daytime sleepiness (34%), cognitive impairment and memory deficits (22%), headache (14%) and epileptic seizures (11%). Conclusions In the Bern region, Switzerland, TBEV was the overall most frequently detected infectious cause, with a clinical manifestation of meningoencephalitis in the majority of cases. Long-term neurological sequelae, most importantly cognitive impairment, fatigue and headache, were frequently self-reported not only in encephalitis and meningoencephalitis survivors but also in viral meningitis survivors up to 40 months after acute infection. |
| Databáze: | OpenAIRE |
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