Effects of selected antidiabetics on weight loss – A retrospective database analysis
| Autor: | Christina Heilmaier, Karel Kostev, T Rockel, J Rex |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Databases Factual medicine.drug_class Endocrinology Diabetes and Metabolism Type 2 diabetes Glucagon-Like Peptide 1 Weight loss Internal medicine Diabetes mellitus Weight Loss Epidemiology Internal Medicine Humans Hypoglycemic Agents Medicine Aged Retrospective Studies Dipeptidyl-Peptidase IV Inhibitors Nutrition and Dietetics business.industry digestive oral and skin physiology Weight change nutritional and metabolic diseases Retrospective cohort study Middle Aged medicine.disease Sulfonylurea Metformin Surgery Sulfonylurea Compounds Treatment Outcome Diabetes Mellitus Type 2 Female medicine.symptom Family Practice business medicine.drug |
| Zdroj: | Primary Care Diabetes. 9:74-77 |
| ISSN: | 1751-9918 |
| DOI: | 10.1016/j.pcd.2014.04.001 |
| Popis: | Aims In published studies metformin was often associated with weight loss in type 2 diabetes patients. Until now, no epidemiological studies have directly compared the effects of DPP-4 and GLP-1 versus metformin on weight loss. Our study is a comparison of sulfonylurea, DPP-4 and GLP-1 with metformin regarding body weight in type 2 diabetes patients. Methods Data from 2641 patients initiated therapy with either metformin, sulfonylurea, DPP-inhibitors or GLP-1 with baseline BMI >30 were retrospectively analyzed (Disease Analyzer Germany: 11/2008–10/2012). Comparison was performed for the weight change after 1 year of therapy compared with the last value prior to therapy. Differences between SU, DPP-4, GLP-1 versus metformin were estimated using regression model adjusted for age, gender, health insurance status, defined co-diagnoses and body weight at baseline. Results In absolute values, metformin patients lost an average of 2.6kg, subjects treated with SU gained 0.3kg, body weight in the DPP-4 group decreased by 1.8kg and GLP-1 patients lost 3.3kg in body weight after 1 year. After adjustment for other variables, comparisons with metformin revealed the following results: SU +3.4kg ( p p =0.003) and GLP-1 −0.4kg ( p =0.589). Conclusion Our study showed that GLP-1 treatment was comparable to metformin regarding the weight reduction, while sulfonylurea and DPP-4 are inferior in this regard. |
| Databáze: | OpenAIRE |
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