| Autor: |
Renner, Philipp, Da Silva, Tomas, Schnitzbauer, Andreas, Verloh, Niklas, Schlitt, Hans-Jürgen, Geissler, Edward K. |
| Jazyk: |
němčina |
| Rok vydání: |
2021 |
| Předmět: |
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| Popis: |
Background Recipient selection for liver transplantation in hepatocellular carcinoma (HCC) is based primarily on criteria affecting the chance of long-term success. Here, the relationship between pretransplant bridging therapy and long-term survival was investigated in a subgroup analysis of the SiLVER Study. Methods Response to bridging, as defined by comparison of imaging at the time of listing and post-transplant pathology report, was categorized into controlled versus progressive disease (more than 20 per cent tumour growth or development of new lesions). Results Of 525 patients with HCC who had liver transplantation, 350 recipients underwent pretransplant bridging therapy. Tumour progression despite bridging was an independent risk factor affecting overall survival (hazard ratio 1.80; P = 0.005). For patients within the Milan criteria (MC) at listing, mean overall survival was longer for those with controlled versus progressive disease (6.8 versus 5.8 years; P |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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