Specific features of amoxicillin‐associated Drug Reaction with Eosinophilia and Systemic Symptoms syndrome: a nationwide study
| Autor: | A.-P. Jonville-Béra, Antoine Pariente, T. Vial, M.-S. Agier, Annabel Maruani, F. Beau-Salinas, B. Largeau |
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| Přispěvatelé: | Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), MethodS in Patients-centered outcomes and HEalth ResEarch (SPHERE), Université de Tours (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR des Sciences Pharmaceutiques et Biologiques, Université de Nantes (UN)-Université de Nantes (UN), Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Bordeaux [Bordeaux], Service Risques, DREAL Nord Pas-de-Calais, Hospices Civils de Lyon (HCL), Centre Hospitalier Régional Universitaire de Tours (CHRU TOURS), Université de Tours-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR des Sciences Pharmaceutiques et Biologiques |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Drug
medicine.medical_specialty Herpesviruses Databases Factual media_common.quotation_subject [SDV]Life Sciences [q-bio] Dermatology Culprit Drug reaction with eosinophilia and systemic symptoms Severe cutaneous adverse reactions 030207 dermatology & venereal diseases 03 medical and health sciences Pharmacovigilance 0302 clinical medicine Internal medicine Eosinophilia polycyclic compounds otorhinolaryngologic diseases Humans Medicine media_common business.industry Drug hypersensitivity syndrome Amoxicillin medicine.disease Pathophysiology 3. Good health Infectious Diseases Drug Hypersensitivity Syndrome 030220 oncology & carcinogenesis Concomitant business DRESS medicine.drug |
| Zdroj: | Journal of the European Academy of Dermatology and Venereology Journal of the European Academy of Dermatology and Venereology, Wiley, 2021, ⟨10.1111/jdv.17631⟩ |
| ISSN: | 0926-9959 1468-3083 |
| Popis: | Background Growing evidence indicates that amoxicillin induces herpesvirus replication in vitro. As these play a central pathophysiological role in Drug Reaction with Eosinophilia and Systemic Symptoms syndrome (DRESS), amoxicillin could present with specific DRESS features. Objective To characterize the onset patterns of amoxicillin-associated DRESS. Methods All cases of DRESS (Kardaun score ≥4) involving amoxicillin and reported in the French Pharmacovigilance Database between January 1, 2004 and November 30, 2019 were included. Onset circumstances for these cases were categorized considering the onset delay from amoxicillin initiation, and the presence of concomitant medications with a compatible time to onset. Results A total of 146 probable cases or definite cases of DRESS were included. Three onset circumstances were identified: (i) 'amoxicillin clear culprit' where amoxicillin was the sole suspect drug or when concomitant drugs of compatible time to onset were not reported to cause DRESS (n = 62); (ii) 'amoxicillin possible culprit' in the presence of other potentially culprit drugs in addition to amoxicillin (n = 44) and (iii) 'flare' where amoxicillin, used after DRESS onset, induced flare-up reactions (n = 40). The median time to onset was 5 days (IQR 2-11) in 'clear culprit', and 18 days (IQR 7-26) in 'possible culprit' cases. In 'flare' cases, the median latency between amoxicillin initiation and flare-up reactions was 3 days (IQR 2-5). Conclusions Amoxicillin can induce DRESS with a specific early onset and exacerbate DRESS from another drug. |
| Databáze: | OpenAIRE |
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