A New 5α,8α-Epidioxysterol from the Soft Coral Sinularia gaweli
| Autor: | Wei-Hsuan Yen, Mei-Chin Lu, Ping-Jyun Sung, Yung-Husan Chen, Yu Hsin Chen, Yin-Di Su, Zhi-Hong Wen, Chan-Shing Lin, Ching-Hsiao Cheng, Yu-Chia Chang, Jui-Hsin Su, Chang-Feng Dai, Wu-Fu Chen, Jyh-Horng Sheu |
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| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Coral
Pharmaceutical Science Antineoplastic Agents HL-60 Cells Tumor cells Sinularia gaweli Article Analytical Chemistry lcsh:QD241-441 Inhibitory Concentration 50 lcsh:Organic chemistry Cell Line Tumor Drug Discovery Animals Humans Physical and Theoretical Chemistry Sinularia Cytotoxicity Spectral data Nuclear Magnetic Resonance Biomolecular Molecular Structure biology Chemistry Organic Chemistry Epidioxysterol Anthozoa biology.organism_classification Sterol Biochemistry epidioxysterol Chemistry (miscellaneous) cytotoxicity Molecular Medicine Cholesterol Esters K562 Cells |
| Zdroj: | Molecules, Vol 18, Iss 3, Pp 2895-2903 (2013) Molecules Molecules; Volume 18; Issue 3; Pages: 2895-2903 |
| ISSN: | 1420-3049 |
| Popis: | A new sterol, (22R,23R,24R)-5α,8α-epidioxy-22,23-methylene-24-methyl-cholest-6,9(11)-dien-3β-ol (1), and two known sterols, (22R,23R,24R)-5α,8α-epidioxy-22,23-methylene-24-methylcholest-6-en-3β-ol (2) and 24-methylenecholestane-1α,3β,5α, 6β,11α-pentol (3), were isolated from the soft coral Sinularia gaweli. The structure of sterol 1 was established by spectroscopic methods and by comparison of the spectral data with those of known analogues. The cytotoxicity of sterols 1–3 towards various tumor cells is reported. |
| Databáze: | OpenAIRE |
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