Tracheal reconstruction with porcine small intestine submucosa in a rabbit model
| Autor: | Mark A. Richardson, Samuel P. Gubbels, Dennis R. Trune, Daphne A. Bascom, Mark K. Wax |
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| Rok vydání: | 2004 |
| Předmět: |
medicine.medical_specialty
Pathology Airway patency Swine Stridor Control animal Surgical Flaps 03 medical and health sciences Random Allocation 0302 clinical medicine Intestine Small Medicine Animals Intestinal Mucosa 030223 otorhinolaryngology Bioprosthesis Tracheal Diseases business.industry Significant difference Granulation tissue respiratory system Plastic Surgery Procedures Small intestine submucosa Surgery Airway Obstruction Trachea medicine.anatomical_structure Treatment Outcome Otorhinolaryngology 030220 oncology & carcinogenesis Case-Control Studies Models Animal Rabbit model Rabbits medicine.symptom business Follow-Up Studies |
| Zdroj: | Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery. 134(6) |
| ISSN: | 0194-5998 |
| Popis: | Objective To evaluate the ability of porcine small intestine submucosa (SIS) to 1) maintain airway patency, 2) integrate, 3) prevent granulation tissue formation, and 4) permit mucosalization when used for tracheal reconstruction. Further studies were performed to evaluate the ability of SIS to support neochondrogenesis and investigate the impact of neochondrogenesis on airway patency. Study design Prospective, controlled animal trial with SIS used with and without a perichondrial flap to reconstruct a tracheal defect in a rabbit model. Functional, histologic and endoscopic analyses were performed. Results All animals except 1 control animal were without stridor. The SIS graft supported neochondrogenesis, was completely mucosalized and was well integrated into the neotrachea. There was minimal granulation tissue formation. Endoscopic analyses did not reveal a consistent, significant difference in airway patency when SIS, with or without a perichondrial flap, was used for reconstruction. Conclusion SIS can be used to reconstruct a sublethal rabbit tracheal defect with no mortality and minimal morbidity. |
| Databáze: | OpenAIRE |
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