Optimum Spray Congealing Conditions for Masking the Bitter Taste of Clarithromycin in Wax Matrix
Autor: | Nobuo Umeki, Shigeru Itai, Toshio Yajima |
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Rok vydání: | 1999 |
Předmět: |
Masking (art)
Wax Scanning electron microscope Stereochemistry Chemistry Drug Compounding General Chemistry General Medicine Matrix (chemical analysis) Solubility Volume (thermodynamics) Clarithromycin Taste Waxes visual_art Specific surface area Drug Discovery Microscopy Electron Scanning visual_art.visual_art_medium Regression Analysis Particle Size Composite material Dissolution Algorithms Antibacterial agent |
Zdroj: | Chemical and Pharmaceutical Bulletin. 47:220-225 |
ISSN: | 1347-5223 0009-2363 |
Popis: | The effects of operating conditions in the spray-congealing process on the release and the micromeritic properties of clarithromycin (CAM) wax matrix were evaluated. CAM wax matrix with 30% CAM, 60% glyceryl monostearate (GM) and 10% aminoalkyl methacrylate copolymer E (AMCE) was manufactured at various atomizer wheel speeds and liquid feed rates with a spray dryer. Release of CAM from the matrix exhibited a two-phase pattern, probably due to the dissolution of the fine portions broken on the surface of the matrix. The slope and the extrapolated y-intercept of the subsequent release pattern were defined as the release rate and the initial amount of release of CAM from the matrix, respectively. These release parameters, as well as the volume median diameter and the specific surface area of matrix, were selected as response variables, and multiple regression analysis was performed. For specific surface area and initial amount of release, a minimum point was observed on the contour curve when the atomizer wheel speed was constant and the liquid feed rate was varied. For the release rate, a maximum point was observed on the contour curve under the same conditions. These points were considered preferable for masking the bitter taste of CAM preparation. Microscopic observation revealed that a small spherical matrix with a smooth surface could be obtained with a high atomizer wheel speed and optimum liquid feed rate. This matrix also possessed excellent properties for taste masking, with small initial amount of release and subsequent high rate of release. In conclusion, the congealing speed of melt droplets was the dominant factor in masking the bitter taste of CAM. |
Databáze: | OpenAIRE |
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