Parotid gland sparing with helical tomotherapy in head-and-neck cancer
| Autor: | Guy Storme, Koen Tournel, Ashraf Farrag, Hendrik Everaert, Dirk Verellen, Maria Voordeckers, Mark De Ridder |
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| Přispěvatelé: | Radiation Therapy, Medical Imaging and Physical Sciences, Translational Radiation Oncology and Physics |
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Adult
Male Cancer Research Saliva medicine.medical_treatment Tomotherapy stomatognathic system medicine Carcinoma Humans Parotid Gland Radiology Nuclear Medicine and imaging Radionuclide Imaging Aged Aged 80 and over Computer. Automation Radiation Lymphatic Irradiation business.industry Head and neck cancer Cancer Radiotherapy Dosage Middle Aged medicine.disease Primary tumor Parotid gland Radiation therapy medicine.anatomical_structure Oncology Head and Neck Neoplasms Carcinoma Squamous Cell Quality of Life Female Radiotherapy Intensity-Modulated Human medicine business Nuclear medicine Organ Sparing Treatments |
| Zdroj: | International journal of radiation oncology, biology, physics Vrije Universiteit Brussel |
| ISSN: | 0360-3016 |
| Popis: | Purpose: This study evaluated the ability of helical tomotherapy to spare the function of the parotid glands in patients with head-and-neck cancer by analyzing dose-volume histograms, salivary gland scintigraphy, and quality of life assessment. Methods and Materials: Data from 76 consecutive patients treated with helical tomotherapy (Hi-Art Tomotherapy) at the University Hospital Brussel were analyzed. During planning, priority was given to planning target volume (PTV) coverage: >= 95% of the dose must be delivered to >= 95% of the PTV. Elective nodal regions received 54 Gy (1.8 Gy/fraction). A dose of 70.5 Gy (2.35 Gy/fraction) was prescribed to the primary tumor and pathologic lymph nodes (simultaneous integrated boost scheme). Objective scoring of salivary excretion was performed by salivary gland scintigraphy. Subjective scoring of salivary gland function was evaluated by the European Organization for Research and Treatment of Cancer quality of life questionnaires Quality of Life Questionnaired-C30 (QLQ-C30) and Quality of Life Questionnaire-Head and Neck 35 (H&N35). Results: Analysis of dose-volume histograms (DVHs) showed excellent coverage of the PTV. The volume of PTV receiving 95% of the prescribed dose (V95%) was 99.4 (range, 96.3-99.9). DVH analysis of parotid gland showed a median value of the mean parotid dose of 32.1 Gy (range, 17.5-70.3 Gy). The median parotid volume receiving a dose |
| Databáze: | OpenAIRE |
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