Serrated adenoma prevalence in inflammatory bowel disease surveillance colonoscopy, and characteristics revealed by chromoendoscopy and virtual chromoendoscopy
| Autor: | Cesare Hassan, Gregory Eustace, Stefan J. Urbanski, Marietta Iacucci, Bertus Eksteen, Gilaad G. Kaplan, Remo Panaccione, Miriam Fort Gasia, Xianyong Gui |
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| Předmět: |
Serrated adenoma
Adenoma Adult Male medicine.medical_specialty Coloring agents Colonic Polyps Gastroenterology Inflammatory bowel disease Chromoendoscopy User-Computer Interface Young Adult Crohn Disease Predictive Value of Tests Internal medicine medicine Humans In patient lcsh:RC799-869 Coloring Agents Aged Retrospective Studies Aged 80 and over Hepatology business.industry General Medicine Colonoscopy Middle Aged medicine.disease digestive system diseases Population Surveillance Colonic Neoplasms Surveillance colonoscopy Colitis Ulcerative Female Original Article lcsh:Diseases of the digestive system. Gastroenterology business |
| Zdroj: | Scopus-Elsevier Canadian Journal of Gastroenterology and Hepatology, Vol 28, Iss 11, Pp 589-594 (2014) |
| Popis: | BACKGROUND: Sessile or nonpolypoid neoplastic lesions, including sessile serrated adenomas (SSAs), are difficult to detect in patients with inflammatory bowel disease (IBD).OBJECTIVES: To assess the prevalence and endoscopic features of SSA in IBD patients undergoing surveillance colonoscopy using novel endoscopic techniques.METHODS: Histology results of biopsies from a cohort of 87 patients (47 men; median age 51.4 years; median duration of disease 16.9 years; ulcerative colitis [n=40], Crohn disease [n=43], ischemic colitis [n=4]) with longstanding colonic IBD undergoing surveillance colonoscopy were reviewed. Lesions of dysplasia (adenoma-like mass, or dysplasia-associated lesion or mass), SSAs, adenoma-like polyps, hyperplastic polyps and inflammatory polyps were identified. Surveillance colonoscopy using high-definition alone, or with iScan (Pentax, USA) dye-sprayed or virtual chromoendoscopy was performed. Lesion characteristics were described before histological diagnosis.RESULTS: Fourteen SSAs were detected in 87 (11%) IBD patients. The endoscopic characteristics of SSA lesions were: nonpolypoid appearance (86%), predominant localization in the proximal colon (79%), >6 mm in size (79%), cloudy cover (64%), Kudo pit pattern modified type IIO (86%) and irregular spiral vascular pattern (79%). Among the 44 SSAs and hyperplastic polyps found in the present study, the above characteristics of SSA at colonoscopy had a sensitivity of 92.86% (95% CI 66.06% to 98.8%) and specificity of 93.33% (95% CI 77.89% to 98.99%) in predicting a histological diagnosis of SSA (positive predictive value 86.67%, negative predictive value 96.55%).CONCLUSION: SSAs are a common finding at surveillance colonoscopy in IBD and have several characteristic features. Further studies are needed to evaluate the natural history of these lesions in IBD patients. |
| Databáze: | OpenAIRE |
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