Indications and results of renal biopsy in children: a 36-year experience
| Autor: | Michele Rossini, Vincenza Carbone, Anna Maria Di Palma, Loreto Gesualdo, Diletta Domenica Torres, Mario Giordano, Luisa Santangelo, Giuseppe Stefano Netti, Marida Martino, Paolo Giordano |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Adolescent 030232 urology & nephrology Gastroenterology Sensitivity and Specificity Nephropathy Cohort Studies Tertiary Care Centers 03 medical and health sciences Young Adult 0302 clinical medicine Focal segmental glomerulosclerosis Glomerulonephritis Sex Factors Internal medicine Biopsy medicine Humans Minimal change disease 030212 general & internal medicine Child Hematuria Retrospective Studies medicine.diagnostic_test business.industry Incidence Biopsy Needle Acute kidney injury Age Factors Infant Glomerulonephritis IGA Acute Kidney Injury medicine.disease Hospitals Pediatric Immunohistochemistry Italy Child Preschool Pediatrics Perinatology and Child Health Female Kidney Diseases Renal biopsy business Nephrotic syndrome |
| Zdroj: | World journal of pediatrics : WJP. 14(2) |
| ISSN: | 1867-0687 |
| Popis: | This study was conducted to investigate retrospectively the indications for renal biopsy (RB) in native kidneys and to analyze pathological findings in a single tertiary pediatric hospital in Southern Italy for the last 36 years. All patients who underwent RB at our hospital from 1979 to 2014 were included. All renal tissue specimens were studied under light and immunofluorescent microscopy, while electron microscopy was performed only for specific clinical indications. The study group included 213 patients (female 43.2%) who underwent 225 percutaneous native kidney biopsies. Median age was 10.4 years (range 0.6–24 years). The most frequent indication for RB was nephrotic syndrome (44.4%), followed by proteinuria (27.6%), asymptomatic hematuria (17.3%) and acute kidney injury (9.8%). Gross hematuria appeared after biopsy in less than 5% of the patients, but none of them needed blood transfusion. Adequate renal tissue sample was obtained in 95.5% of the renal biopsies. Primary glomerulonephritis (GN) was the most common finding (61.4%), followed by secondary GN (21.4%), tubulointerstitial diseases (3.7%) and hereditary nephropathy (2.8%), while in 10.7% of the cases, normal renal tissues were found. According to histopathological diagnosis, the most common causes of primary GN were IgA nephropathy (20.9%), followed by minimal change disease (18.1%) and focal segmental glomerulosclerosis (11.6%). The epidemiology of glomerular disease in our single-center cohort is similar to that shown in other national and international reports. Moreover, our study shows that percutaneous ultrasound-guided RB is a safe, reliable and effective technique in children. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink