Cutaneous Neoplasms in Dogs Associated with Canine Oral Papillomavirus Vaccine
| Autor: | E. F. Christensen, R. S. Hirth, J. P. Sundberg, C. L. Bregman |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
Pathology
medicine.medical_specialty Skin Neoplasms Epidermal Cyst 040301 veterinary sciences Biology Injections Intramuscular 0403 veterinary science 03 medical and health sciences Dogs 0302 clinical medicine Antigen medicine Animals Dog Diseases Papillomavirus Vaccines Papillomaviridae Squamous papilloma Papilloma General Veterinary Transmission (medicine) Viral Vaccines 04 agricultural and veterinary sciences 030224 pathology medicine.disease Basal cell epithelioma Staining Microscopy Electron Tumor Virus Infections Canine oral papillomavirus Carcinoma Basal Cell Carcinoma Squamous Cell |
| Zdroj: | Veterinary Pathology. 24:477-487 |
| ISSN: | 1544-2217 0300-9858 |
| DOI: | 10.1177/030098588702400602 |
| Popis: | A spectrum of proliferative cutaneous lesions occurred in 12 dogs at the injection site of live canine oral papillomavirus (COP) vaccine, suggesting a viral etiology for the masses. Lesions included epidermal hyperplasia, epidermal cysts, squamous papilloma, basal cell epithelioma, and squamous cell carcinoma. Peroxidase-antiperoxidase staining of tumor sections revealed nuclei which stained for group-specific papillomavirus antigen in five of 12 masses. Electron microscopic examination of tumor sections did not reveal virions. In transmission studies, macerated tumor tissue did not produce oral papillomas on the scarified mucosa of puppies; this procedure did protect the puppies from development of lesions when challenged with infectious papilloma material. These findings are evidence that COP can induce hyperplastic and neoplastic lesions in sites other than oral, pharyngeal, and ocular mucosa. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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