Altered intensity coding in the salicylate-overdose animal model of tinnitus
| Autor: | Tzai-Wen Chiu, Petr Lansky, Ilynn Wan, Ondrej Pokora, Paul W.F. Poon |
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| Rok vydání: | 2015 |
| Předmět: |
Statistics and Probability
Normal conditions business.industry Loudness Perception Applied Mathematics Salicylate overdose Information Storage and Retrieval General Medicine Stimulus (physiology) Salicylates General Biochemistry Genetics and Molecular Biology Rats Rats Sprague-Dawley Tinnitus Animal model Acoustic Stimulation Modeling and Simulation Evoked Potentials Auditory otorhinolaryngologic diseases Animals Medicine medicine.symptom business Neuroscience |
| Zdroj: | Biosystems. 136:113-119 |
| ISSN: | 0303-2647 |
| DOI: | 10.1016/j.biosystems.2015.06.010 |
| Popis: | Tinnitus is one of the leading disorders of hearing with no effective cure as its pathophysiological mechanisms remain unclear. While the sensitivity to sound is well-known to be affected, exactly how intensity coding per se is altered remains unclear. To address this issue, we used a salicylate-overdose animal model of tinnitus to measure auditory cortical evoked potentials at various stimulus levels, and analyzed on single-trial basis the response strength and its variance for the computation of the lower bound of Fisher information. Based on Fisher information profiles, we compared the precision or efficiency of intensity coding before and after salicylate-treatment. We found that after salicylate treatment, intensity coding was unexpectedly improved, rather than impaired. Also, the improvement varied in a sound-dependent way. The observed changes are likely due to some central compensatory mechanisms that are activated during tinnitus to bring out the full capacity of intensity coding which is expressed only in part under normal conditions. |
| Databáze: | OpenAIRE |
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