Interleukin-2 gene has superior antinociceptive effects when delivered intrathecally
| Autor: | Ming-Zhong Yao, Lan-Ying Sun, Jinfa Gu, Huan Liu, Xinyuan Liu, Jin-Hui Wang, Zhi-Qi Zhao |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Male
Interleukin 2 DNA Complementary Injections Subcutaneous Genetic enhancement medicine.medical_treatment Genetic Vectors Analgesic Gene Expression Pain Pharmacology law.invention Rats Sprague-Dawley law medicine Animals Cation Exchange Resins Gene Injections Spinal Afferent Pathways Liposome Dose-Response Relationship Drug business.industry General Neuroscience Nociceptors Genetic Therapy Lipids Rats Posterior Horn Cells Nociception Cytokine Recombinant DNA Interleukin-2 Indicators and Reagents business Plasmids medicine.drug |
| Zdroj: | Neuroreport. 13:791-794 |
| ISSN: | 0959-4965 |
| DOI: | 10.1097/00001756-200205070-00011 |
| Popis: | The antinociceptive effect of interleukin-2 gene on rat carrageenan-induced pain was explored using different delivery methods. Intrathecal (i.t.) or plantar s.c. delivery of plasmid harbouring the interleukin-2 gene produced a marked antinociceptive effect, which was maintained up to 6 days; the administration of recombinant human interleukin-2 only had a transitory effect. The antinociceptive effect lasted longer and was more potent when the interleukin-2 gene was administered i.t. than when delivered s.c. The effect of the interleukin-2 gene was related to its protein expression, was dose dependent, and could be potentiated by liposome. The results suggest that the interleukin-2 gene has a good prospect for clinical use. |
| Databáze: | OpenAIRE |
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