| Popis: |
Summary 1. Thirty instances of normal Rh negative infants born to sensitized Rh-negative mothers were studied. 2. Small amounts of Rh antibodies (2+ or less) occurring inconsistently in ante-partum tests were regarded as nonspecific and of no significance. 3. The tests for Rh sensitization showed appreciable amounts of Rh antibodies to be consistently present in the sera of 17 Rh-negative women who subsequently bore Rh-negative infants. In seven instances the ante-partum antibody titer increased in intensity and in ten instances the antibody titer remained constant. 4. All women in whom the antibody titers were consistently present (Group I) showed evidences of a high degree of Rh immunization in terms of the amount and type of antibody present, and in some instances by having previously borne an erythroblastotic infant. 5. The only basis for the prediction of an Rh-negative infant to be borne of a sensitized Rh-negative woman is first, the determination of the Hr status of the husband, and second, the trend of the maternal ante partum Rh antibody titer. If the husband is heterozygous (Rhrh) and the titer remains constant, the baby will likely be Rh negative; however, some highly immunized Rh negative women may actually demonstrate a rising Rh antibody titer and still bear an Rh-negative infant. |
