Antinociceptive Effects of a Chloroform Extract and the Alkaloid Dicentrine Isolated from Fruits of Ocotea puberula
| Autor: | Alcı́bia M Cardozo, Gabriel Araujo da Silva, Sandra Maria Warumby Zanin, Deise Prehs Montrucchio, Obdulio Gomes Miguel, Adair R.S. Santos |
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| Rok vydání: | 2012 |
| Předmět: |
Male
Aporphines Stereochemistry Pain Pharmaceutical Science Adenosinergic (+)-Naloxone Pharmacology Adenosine receptor antagonist Nociceptive Pain Analytical Chemistry Mice chemistry.chemical_compound Alkaloids Formaldehyde Dicentrine Drug Discovery Animals Acetic Acid Pain Measurement Ocotea puberula Dose-Response Relationship Drug Molecular Structure biology Plant Extracts Chemistry Alkaloid Organic Chemistry biology.organism_classification Analgesics Opioid Muscle relaxation Ocotea Complementary and alternative medicine Fruit Molecular Medicine Chloroform Caffeine |
| Zdroj: | Planta Medica. 78:1543-1548 |
| ISSN: | 1439-0221 0032-0943 |
| DOI: | 10.1055/s-0032-1315026 |
| Popis: | The present work describes the chemical characterization of a chloroform fraction (CF) obtained from an extract of Ocotea puberula (Lauraceae) fruits, and preliminary antinociceptive analysis of CF and the alkaloid dicentrine, isolated from this fraction. CF (30-300 mg/kg, p. o.) caused dose-related inhibition of abdominal constrictions caused by acetic acid and also inhibited both phases of formalin-induced nociception. However, hexane or ethyl acetate fractions did not produce any effect. Antinociception caused by CF (100 mg/kg, p. o.) in the acetic acid test was not affected either by caffeine, an adenosine receptor antagonist, or by naloxone, an opioid receptor antagonist, and neither was associated with nonspecific effects such as muscle relaxation or sedation. Furthermore, dicentrine (30-300 mg/kg, p. o.) produced dose-related inhibition of acetic acid-induced pain without causing changes in the motor performance of mice. The results show, for the first time, that CF from Ocotea puberula fruits produced marked antinociception in different models of chemical pain, and this effect appears to be, at least in part, due to the presence of dicentrine. The mechanism by which CF and the alkaloid produced antinociception still remains unclear, but the adenosinergic or opioid system seems unlikely to be involved in this action. |
| Databáze: | OpenAIRE |
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