Apolipoproteins A-I and B in Kuwaiti Children
| Autor: | David Nkansa-Dwamena, Mohamed A.A. Moussa, Mohammad Mourad, Azza A. Shaltout |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Blood Glucose
Male medicine.medical_specialty Adolescent Apolipoprotein B Lipoproteins medicine.medical_treatment Medicine (miscellaneous) Low density lipoprotein cholesterol Apolipoproteins A Body Mass Index Internal medicine Blood plasma medicine Humans Insulin Obesity Child Triglycerides Pancreatic hormone Apolipoproteins B Body fat distribution Nutrition and Dietetics Apolipoprotein A-I biology business.industry Cholesterol HDL Cholesterol LDL medicine.disease Cholesterol Endocrinology Kuwait Case-Control Studies biology.protein Body Constitution Female lipids (amino acids peptides and proteins) business |
| Zdroj: | Annals of Nutrition and Metabolism. 42:202-210 |
| ISSN: | 1421-9697 0250-6807 |
| DOI: | 10.1159/000012735 |
| Popis: | To assess the relation of apolipoproteins (Apos) A-I and B (the carrier proteins for high and low density lipoprotein cholesterol, respectively) with the degree of obesity, body fat distribution, serum lipids, glucose and insulin levels, a case-control study was carried out and included 460 Kuwaiti obese children, 6–13 years old, matched by age and sex to 460 normal-weight controls. Obese children were ascertained in a representative cross-sectional study of 2,400 school children. The Apo A-I levels were not different between obese and non-obese boys, while they were significantly lower in obese girls (p < 0.01). The Apo B mean concentrations were significantly higher in obese boys and girls (p < 0.001), while the Apo A-I:B ratio was significantly lower in obese children (p < 0.001). Apo A-I levels were positively correlated with total cholesterol, high- and low-density lipoprotein cholesterol, but were not correlated with very low-density lipoprotein cholesterol, triglycerides, insulin, glucose or insulin:glucose ratio. Apo B levels were negatively correlated with high-density lipoprotein cholesterol and positively correlated with insulin and insulin:glucose ratio (p < 0.01) in obese children. The study documented an adverse Apo profile in obese Kuwaiti children. Since Apo changes are correctable through management of obesity, their identification in childhood offers prospects for prevention of early onset atherogenesis in adulthood. |
| Databáze: | OpenAIRE |
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