Prevalence and Clinical Significance of Helicobacter Pylori-negative Chronic Gastritis in Children

Autor: Anni Virkkula, Laura Kivela, Pauliina Hiltunen, Antti Sotka, Heini Huhtala, Kalle Kurppa, Marleena Repo
Přispěvatelé: Tampere University, Clinical Medicine, Department of Paediatrics, Health Sciences, Seinäjoen keskussairaala VA
Rok vydání: 2022
Předmět:
Zdroj: Journal of pediatric gastroenterology and nutrition. 74(5)
ISSN: 1536-4801
Popis: OBJECTIVES: The clinical significance of Helicobacter pylori-negative chronic gastritis (HPNCG) in children is unclear. We examined this issue in patients who had undergone esophagogastroduodenoscopy with systematic gastric sampling. METHODS: Data of 1178 consecutive children who underwent diagnostic esophagogastroduodenoscopy were collected. Baseline characteristics and long-term outcomes were compared between children with active and inactive HPNCG and those with normal gastric histology. Follow-up data were available for up to 13 years. RESULTS: Altogether 24 (2.0%) children had active and 235 (19.9%) inactive HPNCG, 27 (2.3%) were Hpylori-positive, 46 (3.9%) had other gastric pathology, and 846 (71.8%) normal histology. Diarrhea (31.3% vs 25.1%, P = 0.033), poor growth (23.6% vs 14.7%, P
Databáze: OpenAIRE