New Insights into Multiple Sclerosis Mechanisms: Lipids on the Track to Control Inflammation and Neurodegeneration

Autor: Anna Pokryszko-Dragan, Maria Podbielska, Joan O’Keeffe
Jazyk: angličtina
Rok vydání: 2021
Předmět:
0301 basic medicine
Multiple Sclerosis
QH301-705.5
Central nervous system
Axonal loss
Inflammation
Review
Disease
Neuroprotection
Catalysis
MS therapy
Inorganic Chemistry
Central nervous system disease
lipids
03 medical and health sciences
0302 clinical medicine
Central Nervous System Diseases
medicine
Animals
Humans
Physical and Theoretical Chemistry
Biology (General)
Molecular Biology
QD1-999
Myelin Sheath
Spectroscopy
business.industry
Multiple sclerosis
Organic Chemistry
Neurodegeneration
neurodegeneration
Neurodegenerative Diseases
General Medicine
medicine.disease
central nervous system
Computer Science Applications
MS biomarkers
Chemistry
030104 developmental biology
medicine.anatomical_structure
inflammation
MS mechanisms
lipidomics
medicine.symptom
business
Neuroscience
neurological diseases
030217 neurology & neurosurgery
Zdroj: International Journal of Molecular Sciences, Vol 22, Iss 7319, p 7319 (2021)
International Journal of Molecular Sciences
ISSN: 1661-6596
1422-0067
Popis: Multiple sclerosis (MS) is a central nervous system disease with complex pathogenesis, including two main processes: immune-mediated inflammatory demyelination and progressive degeneration with axonal loss. Despite recent progress in our understanding and management of MS, availability of sensitive and specific biomarkers for these both processes, as well as neuroprotective therapeutic options targeted at progressive phase of disease, are still being sought. Given their abundance in the myelin sheath, lipids are believed to play a central role in underlying immunopathogenesis in MS and seem to be a promising subject of investigation in this field. On the basis of our previous research and a review of the literature, we discuss the current understanding of lipid-related mechanisms involved in active relapse, remission, and progression of MS. These insights highlight potential usefulness of lipid markers in prediction or monitoring the course of MS, particularly in its progressive stage, still insufficiently addressed. Furthermore, they raise hope for new, effective, and stage-specific treatment options, involving lipids as targets or carriers of therapeutic agents.
Databáze: OpenAIRE
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