Temporal and extratemporal atrophic manifestation of temporal lobe epilepsy using voxel-based morphometry and corticometry: clinical application in lateralization of epileptogenic zone
| Autor: | Masoud Hassanpour, Roya Sharifpour, Milad Seyfi, Seyed Sohrab Hashemi-Fesharaki, Majdi Mousa Jber, Mohammad Reza Ay, Ahmedreza Keihani, Neda Mohammadi Mobarakeh, Mohammad-Reza Nazem-Zadeh, Hengameh Marzbani, Jafar Mehvari Habibabadi |
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| Rok vydání: | 2020 |
| Předmět: |
Thalamus
Hippocampus Dermatology computer.software_genre behavioral disciplines and activities Lateralization of brain function Temporal lobe 03 medical and health sciences Epilepsy 0302 clinical medicine Voxel medicine Image Processing Computer-Assisted Humans 030212 general & internal medicine Gray Matter Neuroradiology business.industry General Medicine Voxel-based morphometry Anatomy medicine.disease Magnetic Resonance Imaging Temporal Lobe nervous system diseases Psychiatry and Mental health nervous system Epilepsy Temporal Lobe Neurology (clinical) Atrophy business computer psychological phenomena and processes 030217 neurology & neurosurgery |
| Zdroj: | Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. 42(8) |
| ISSN: | 1590-3478 |
| Popis: | Advances in MRI acquisition and data processing have become important for revealing brain structural changes. Previous studies have reported widespread structural brain abnormalities and cortical thinning in patients with temporal lobe epilepsy (TLE), as the most common form of focal epilepsy. In this research, healthy control cases (n = 20) and patients with left TLE (n = 19) and right TLE (n = 14) were recruited, all underwent 3.0 T MRI with magnetization-prepared rapid gradient echo sequence to acquire T1-weighted images. Morphometric alterations in gray matter were identified using voxel-based morphometry (VBM). Volumetric alterations in subcortical structures and cortical thinning were also determined. Patients with left TLE demonstrated more prevailing and widespread changes in subcortical volumes and cortical thickness than right TLE, mainly in the left hemisphere, compared to the healthy group. Both VBM analysis and subcortical volumetry detected significant hippocampal atrophy in ipsilateral compared to contralateral side in TLE group. In addition to hippocampus, subcortical volumetry found the thalamus and pallidum bilaterally vulnerable to the TLE. Furthermore, the TLE patients underwent cortical thinning beyond the temporal lobe, affecting gray matter cortices in frontal, parietal, and occipital lobes in the majority of patients, more prevalently for left TLE cases. Exploiting volume changes in individual patients in the hippocampus alone led to 63.6% sensitivity and 100% specificity for lateralization of TLE. Alteration of gray matter volumes in subcortical regions and neocortical temporal structures and also cortical gray matter thickness were evidenced as common effects of epileptogenicity, as manifested by the majority of cases in this study. |
| Databáze: | OpenAIRE |
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