Concomitant genetic alterations are associated with plasma D-dimer level in patients with non-small-cell lung cancer
Autor: | Chen Chen, Meiling Zhao, Zhangyan Ke, Hao Zhang, Xiaoyun Fan, Yanbei Zhang, Fangqun Chang |
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Rok vydání: | 2022 |
Předmět: |
Male
Oncology Cancer Research medicine.medical_specialty Lung Neoplasms Gene mutation medicine.disease_cause Fibrin Fibrinogen Degradation Products Predictive Value of Tests Risk Factors Carcinoma Non-Small-Cell Lung Internal medicine Biomarkers Tumor ROS1 medicine Humans Risk factor Family history Lung cancer Aged Mutation business.industry High-Throughput Nucleotide Sequencing General Medicine Middle Aged Prognosis medicine.disease Survival Analysis Logistic Models ROC Curve Concomitant Female KRAS business |
Zdroj: | Future Oncology. 18:679-690 |
ISSN: | 1744-8301 1479-6694 |
Popis: | Objective: D-dimer is correlated to the poor prognosis of non-small-cell lung cancer. The study aimed to investigate the association between plasma D-dimer and concomitant mutations in non-small-cell lung cancer. Methods: A total of 517 non-small-cell lung cancer patients were recruited and tested for ALK, BRAF, EGFR, HER2/ERBB2, KRAS, MET, PIK3CA, RET and ROS1 mutation by next-generation sequencing. Multiple gene mutation information, clinical baseline data and laboratory test data were analyzed statistically. Results: All patients were divided into three groups: wild-type group, single-gene mutation group and concomitant mutation group. The analysis of D-dimer, uric acid, gender, family history, smoking history, histology and distant metastasis all showed significant differences in the three groups (p |
Databáze: | OpenAIRE |
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