CircRNA_45478 promotes ischemic AKI by targeting the miR ‐190a‐5p/ PHLPP1 axis

Autor: Yingjun, Liao, Xiongjun, Peng, Xiaozhou, Li, Dengke, Wu, Shuangfa, Qiu, Xianming, Tang, Dongshan, Zhang
Rok vydání: 2022
Předmět:
Zdroj: The FASEB Journal. 36
ISSN: 1530-6860
0892-6638
Popis: A few studies suggested that circular RNAs were involved in the development of ischemic acute kidney injury (AKI). However, the function and regulation mechanism of circRNA_45478 in ischemic AKI remains unknown. In the present study, ischemic injury induced the expressions of circRNA_45478 in mouse proximal tubule-derived cell lines (BUMPT cells) and kidneys of C57BL/6 mice. Functionally, circRNA_45478 mediated I/R-induced apoptosis in BUMPT cells. Mechanistically, circRNA_45478 upregulated the expression of Pleckstrin homology (PH) domain leucine-rich repeat protein phosphatase 1 (PHLPP1) via sponging of microRNA (miR)-190a-5p. Finally, inhibition of circRNA_45478 significantly alleviated the progression of ischemic AKI through regulation of the miR-190a-5p/PHLPP1 pathway. Taken together, our data showed that circRNA_45478/miR-190a-5p/PHLPP1 axis mediated the progression of ischemic AKI.
Databáze: OpenAIRE
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