The Effects of Portulaca oleracea on Hypoxia-Induced Pulmonary Edema in Mice
| Autor: | Li Min, Wen Xiaosa, Qi Ruirui, Shi Wencai, Xin Hailiang, Tan Yue |
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| Rok vydání: | 2015 |
| Předmět: |
Male
Scientific Articles Antioxidant Time Factors Physiology medicine.medical_treatment Pulmonary Edema Portulaca Pharmacology Altitude Sickness medicine.disease_cause law.invention Capillary Permeability chemistry.chemical_compound Mice Downregulation and upregulation law medicine Animals Lung Mice Inbred BALB C Ethanol biology business.industry Plant Extracts Public Health Environmental and Occupational Health NF-kappa B General Medicine Hypoxia (medical) Pulmonary edema medicine.disease biology.organism_classification Oxidative Stress chemistry Immunology Cytokines medicine.symptom Phytotherapy business Cell Adhesion Molecules Oxidative stress |
| Zdroj: | High altitude medicinebiology. 16(1) |
| ISSN: | 1557-8682 |
| Popis: | Tan Yue, Wen Xiaosa, Qi Ruirui, Shi Wencai, Xin Hailiang, and Li Min. The effects of Portulaca oleracea on hypoxia-induced pulmonary edema in mice. High Alt Med Biol 16:43–51, 2015—Portulaca oleracea L. (PO) is known as “a vegetable for long life” due to its antioxidant, anti-inflammatory, and other pharmacological activities. However, the protective activity of the ethanol extract of PO (EEPO) against hypoxia-induced pulmonary edema has not been fully investigated. In this study, we exposed mice to a simulated altitude of 7000 meters for 0, 3, 6, 9, and 12 h to observe changes in the water content and transvascular leakage of the mouse lung. It was found that transvascular leakage increased to the maximum in the mouse lung after 6 h exposure to hypobaric hypoxia. Prophylactic administration of EEPO before hypoxic exposure markedly reduced the transvascular leakage and oxidative stress, and inhibited the upregulation of NF-kB in the mouse lung, as compared with the control group. In addition, EEPO significantly reduced the levels of proinflammatory cytokines and cell adhesion molecules in the lungs of mice, as compared with the hypoxia group. Our results show that EEPO can reduce initial transvascular leakage and pulmonary edema under hypobaric hypoxia conditions. |
| Databáze: | OpenAIRE |
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