Sex hormone-binding globulin mediates steroid hormone signal transduction at the plasma membrane
| Autor: | Atif M. Nakhla, William Rosner, D J Hryb, M. Saeed Khan, Nicholas A. Romas |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
medicine.medical_specialty
Endocrinology Diabetes and Metabolism medicine.medical_treatment Clinical Biochemistry Biochemistry Second Messenger Systems Steroid Adenylyl cyclase chemistry.chemical_compound Endocrinology Sex hormone-binding globulin Internal medicine Sex Hormone-Binding Globulin polycyclic compounds medicine Humans Receptor Molecular Biology reproductive and urinary physiology biology Cell Membrane Cell Biology Sex hormone receptor Steroid hormone chemistry Second messenger system biology.protein Molecular Medicine Steroids hormones hormone substitutes and hormone antagonists Hormone Signal Transduction |
| Zdroj: | The Journal of steroid biochemistry and molecular biology. 69(1-6) |
| ISSN: | 0960-0760 |
| Popis: | Sex hormone-binding globulin is a plasma glycoprotein that binds certain estrogens and androgens with high affinity. Over the past several years it has been shown that, in addition to functioning as a regulator of the free concentration of a number of steroid hormones, SHBG plays a central role in permitting certain steroid hormones to act without entering the cell. The system is complex. SHBG interacts with a specific, high affinity receptor (R(SHBG)) on cell membranes that appears to transduce its signal via a G protein. The SHBG-R(SHBG) complex causes the activation of adenylyl cyclase and the generation of cAMP within a matter of minutes after exposure to an appropriate steroid. Only steroids that bind to SHBG can activate SHBG-R(SHBG), but not all steroids that bind have this function, e.g. are agonists. All steroids that bind to SHBG but do not activate adenylyl cyclase are antagonists. The signals generated by the steroid-SHBG-R(SHBG) complex generate messages that have effects on the transcriptional activity of classic, intracellular receptors for steroid hormones. These and other downstream effects of this system are reviewed. |
| Databáze: | OpenAIRE |
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