Domains of Daily Physical Activity in Children with Mitochondrial Disease
| Autor: | Koene, Saskia, Dirks, Ilse, van Mierlo, Esmee, de Vries, Pascal R., Janssen, Anja J.W.M., Smeitink, Jan A.M., Bergsma, Arjen, Hans, Essers, Meijer, Kenneth, de Groot, Imelda J. M., Morava, Eva, Baumgartner, Matthias, Patterson, Marc, Rahman, Shamima, Zschocke, Johannes, Peters, Verena |
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| Přispěvatelé: | RS: NUTRIM - R3 - Respiratory & Age-related Health, RS: NUTRIM - HB/BW section B, RS: NUTRIM - R3 - Chronic inflammatory disease and wasting |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty business.industry Mitochondrial disease Area under the curve Accelerometer medicine.disease Article Intensity (physics) Clinical trial 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Physical medicine and rehabilitation Ambulatory Medicine Observational study business 030217 neurology & neurosurgery Face validity |
| Zdroj: | JIMD Reports, 36, 7-17 JIMD Reports, 6, 7-17 JIMD Reports ISBN: 9783662561379 |
| DOI: | 10.1007/8904_2016_35 |
| Popis: | Feasible, sensitive and clinically relevant outcome measures are of extreme importance when designing clinical trials. For paediatric mitochondrial disease, no robust end point has been described to date. The aim of this study was to select the domains of daily physical activity, which can be measured by 3D accelerometry, that could serve as sensitive end points in future clinical trials in children with mitochondrial disorders.In this exploratory observational study, 17 patients with mitochondrial disease and 16 age- and sex-matched controls wore 3D accelerometers at the upper leg, upper arm, lower arm and chest during one weekend. Using the raw data obtained by the accelerometers, we calculated the following outcome measures: (1) average amount of counts per hour the sensors were worn; (2) the maximal intensity; (3) the largest area under the curve during 30 min and (4) categorized activities lying, standing or being dynamically active. Measuring physical activity during the whole weekend was practically feasible in all participants. We found good face validity by visually correlating the validation videos and activity diaries to the accelerometer data-graphs. Patients with mitochondrial disorders had significantly lower peak intensity and were resting more, compared to their age- and sex-matched peers.Finally, we suggest domains of physical activity that could be included when measuring daily physical activity in children with mitochondrial disorders, preferably using more user-friendly devices. These include peak activity parameters for the arms (all patients) and legs (ambulatory patients). We recommend using or developing devices that measure these domains of physical activity in future clinical studies. |
| Databáze: | OpenAIRE |
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