TRP's: Links to schizophrenia?
| Autor: | Loris A. Chahl |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Dopamine
medicine.medical_treatment Thermoregulation behavioral disciplines and activities Receptors Dopamine Transient receptor potential channel Transient Receptor Potential Channels Neurodevelopmental disorder mental disorders medicine Animals Humans Neurons Afferent Receptors Cannabinoid Molecular Biology TRP channels business.industry Dopaminergic Brain medicine.disease Rats Schizophrenia Synapses Molecular Medicine Sensory system Cannabinoid Capsaicin business Neuroscience Body Temperature Regulation medicine.drug |
| Zdroj: | Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1772:968-977 |
| ISSN: | 0925-4439 |
| Popis: | Schizophrenia is a chronic psychiatric disorder the cause of which is unknown. It is considered to be a neurodevelopmental disorder that results from an interaction of genetic and environmental factors. Direct evidence for links between schizophrenia and TRP channels is lacking. However, several aspects of the pathophysiology of the disorder point to a possible involvement of TRP channels. In this review evidence for links between TRP channels and schizophrenia with respect to neurodevelopment, dopaminergic and cannabinoid systems, thermoregulation, and sensory processes, is discussed. Investigation of these links holds the prospect of a new understanding of schizophrenia with resultant therapeutic advances. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect