Digestive n‐6 Lipid Oxidation, a Key Trigger of Vascular Dysfunction and Atherosclerosis in the Western Diet: Protective Effects of Apple Polyphenols

Autor: S. Risdon, Claire Dufour, Gaetan Bolea, Mathilde Dubois, Grégory Meyer, Bernard Geny, Clothilde Philouze, Cyril Reboul, Christian Ginies, Claire Arnaud, Anne-Laure Charles, Anaïs Humberclaude
Přispěvatelé: EA4278 Laboratoire de Pharm-Ecologie Cardiovasculaire (LaPEC), Avignon Université (AU), Sécurité et Qualité des Produits d'Origine Végétale (SQPOV), Avignon Université (AU)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Fédération de Médecine Translationnelle de Strasbourg (FMTS), Université de Strasbourg (UNISTRA), Mitochondrie, stress oxydant et protection musculaire (MSP), Hypoxie : Physiopathologie Respiratoire et Cardiovasculaire (HP2), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Grenoble Alpes (UGA)
Jazyk: angličtina
Rok vydání: 2021
Předmět:
0301 basic medicine
Male
Antioxidant
4-hydroxy-2-nonenal
Mice
Knockout
ApoE
medicine.medical_treatment
[SDV]Life Sciences [q-bio]
medicine.disease_cause
Nitric Oxide
03 medical and health sciences
Lipid oxidation
endothelial function
Fatty Acids
Omega-6
[SDV.BC.IC]Life Sciences [q-bio]/Cellular Biology/Cell Behavior [q-bio.CB]
medicine
Animals
Food science
Endothelial dysfunction
Western diet
[SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry
Molecular Biology/Biochemistry [q-bio.BM]
ComputingMilieux_MISCELLANEOUS
2. Zero hunger
chemistry.chemical_classification
Aldehydes
030109 nutrition & dietetics
Chemistry
food and beverages
Polyphenols
medicine.disease
Atherosclerosis
Plaque
Atherosclerotic
3. Good health
Lipoproteins
LDL
Mice
Inbred C57BL
030104 developmental biology
Proanthocyanidin
Polyphenol
Diet
Western
Malus
Dietary Supplements
lipids (amino acids
peptides
and proteins)
Digestion
Reactive Oxygen Species
[SDV.AEN]Life Sciences [q-bio]/Food and Nutrition
Oxidation-Reduction
Oxidative stress
Food Science
Biotechnology
Polyunsaturated fatty acid
Zdroj: Molecular Nutrition and Food Research
Molecular Nutrition and Food Research, Wiley-VCH Verlag, 2021, 65 (6), pp.2000487. ⟨10.1002/mnfr.202000487⟩
Molecular Nutrition and Food Research, Wiley-VCH Verlag, 2021, pp.2000487. ⟨10.1002/mnfr.202000487⟩
ISSN: 1613-4125
1613-4133
Popis: International audience; Scope: A main risk factor of atherosclerosis is a Western diet (WD) rich in n-6 polyunsaturated fatty acids (PUFAs) sensitive to oxidation. Their oxidation can be initiated by heme iron of red meat leading to the formation of 4-hydroxy-2-nonenal (4-HNE), a cytotoxic aldehyde. An increased 4-HNE production is implicated in endothelial dysfunction and atherosclerosis. By contrast, a diet rich in proanthocyanidins reduces oxidative stress and arterial diseases. This study evaluates the effects of a WD on vascular integrity in ApolipoproteinE (ApoE−/−) mice and the protective capacity of apple extract and puree rich in antioxidant proanthocyanidins.Methods and results: ApoE-/- mice are fed during 12 weeks with a WD with or without n-6 PUFAs. Moreover, two WD + n-6 PUFAs groups are supplemented with apple puree or phenolic extract. An increase in digestive 4-HNE production associated with a rise in plasmatic 4-HNE and oxidized LDL concentrations is reported. Oxidizable n-6 PUFAs consumption is associated with a worsened endothelial dysfunction and atherosclerosis. Interestingly, supplementations with apple polyphenol extract or puree prevented these impairments while reducing oxidative stress.Conclusion: n-6 lipid oxidation during digestion may be a key factor of vascular impairments. Nevertheless, an antioxidant strategy can limit 4-HNE formation during digestion and thus durably protect vascular function.
Databáze: OpenAIRE
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