Effect of increased interstitial fluid flux on fractional catabolic rate of high molecular weight [3H]hyaluronan injected in rabbit skin
| Autor: | Suzanne N. King, T. C. Laurent, Rolf K. Reed, Ulla B.G. Laurent, J. R. E. Fraser |
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| Rok vydání: | 1996 |
| Předmět: |
Male
medicine.medical_specialty Injections Intradermal Physiology Injections Subcutaneous Connective tissue Hemodynamics Blood Pressure Glycosaminoglycan chemistry.chemical_compound Body Water Interstitial fluid Internal medicine Hyaluronic acid medicine Animals Hyaluronic Acid Skin Lagomorpha biology biology.organism_classification Molecular Weight Kinetics Lymphatic system medicine.anatomical_structure Endocrinology chemistry Biochemistry Lymph Rabbits Extracellular Space |
| Zdroj: | Acta physiologica Scandinavica. 156(2) |
| ISSN: | 0001-6772 |
| Popis: | The removal rate of high molecular weight (M r 3 x 10 6 ) [ 3 H]hyaluronan has been measured in rabbit paw skin in control and during increased local venous pressure induced by ligation of the femoral vein The increased venous pressure resulted in a 20% increase of interstitial volume at 4 h after ligation, a value which relates to at least a doubling of lymph flow, i.e. also to doubling of fluid flux through the tissues. The fractional catabolic rate of hyaluronan was 0.0918 ± 0.0170 h -1 (n = 10) and 0.0775 ± 0.0206 h -1 (n = 11) in control and following increased venous pressure respectively (P > 0.05). Since the fractional catabolic rate of hyaluronan is not affected by increased venous pressure, the removal of hyaluronan via lymphatic drainage in rabbit paw skin must be small compared to the local turnover of the polysaccharide. |
| Databáze: | OpenAIRE |
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