Vitamin D receptor Fokl polymorphism is a determinant of both maternal and neonatal vitamin D concentrations at birth
| Autor: | Declan P. Naughton, Hana Fakhoury, Vikentia Harizopoulou, Merve Alaylıoğlu, Spyridon N. Karras, Vasiliki Antonopoulou, Stefan Pilz, Duygu Gezen-Ak, Fatme Al Anouti, Cédric Annweiler, Kalliopi Kotsa, Dimitrios G. Goulis, Theocharis Koufakis, Pantelis Zebekakis, Erdinç Dursun |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Adult Male medicine.medical_specialty TaqI Genotype Offspring Endocrinology Diabetes and Metabolism Clinical Biochemistry Rickets alliedhealth Biochemistry Calcitriol receptor Polymorphism Single Nucleotide vitamin D deficiency 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Endocrinology Pregnancy Risk Factors Internal medicine medicine Vitamin D and neurology Humans Genetic Predisposition to Disease Vitamin D Molecular Biology Genetic Association Studies biology business.industry Infant Newborn Cell Biology medicine.disease Vitamin D Deficiency FokI 030104 developmental biology chemistry 030220 oncology & carcinogenesis biology.protein Molecular Medicine Receptors Calcitriol Female business |
| Zdroj: | The Journal of steroid biochemistry and molecular biology. 199 |
| ISSN: | 1879-1220 0960-0760 |
| Popis: | Maternal vitamin D deficiency is considered to be the key determinant of the development of neonatal vitamin D deficiency at birth and during early infancy. Specific vitamin D receptor (VDR) gene polymorphisms have been associated with adverse pregnancy and offspring outcomes. The aim of this study was to evaluate the effect of maternal and neonatal VDR polymorphisms (ApaI, TaqI, BsmI, FokI, Tru9I) on maternal and neonatal vitamin D status. VDR polymorphisms were genotyped in 70 mother-neonate pairs of Greek origin, and classified according to international thresholds for Vitamin D status. Mean neonatal and maternal 25-hydroxy-vitamin D [25(OH)D] concentrations were 35 ± 20 and 47 ± 26 nmol/l, respectively. Neonatal VDR polymorphisms were not associated with neonatal 25(OH)D concentrations. In contrast, mothers with the Fokl FF polymorphism had a 70 % lower risk of vitamin D deficiency [25(OH)D |
| Databáze: | OpenAIRE |
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