Utility of Liver Function Tests and Fatty Liver Index to Categorize Metabolic Phenotypes in a Mediterranean Population

Autor: María Rosa Bernal-López, Verónica Buonaiuto, Josefina Ruiz-Nava, Dariusz Narankiewicz, Luis M. Pérez-Belmonte, Maria Isabel Ruiz-Moreno, Ricardo Gómez-Huelgas, María D. López-Carmona
Přispěvatelé: [Narankiewicz,D] Preventive Medicine Department, Virgen de la Victoria University Hospital, Malaga, Spain. [Ruiz-Nava,J, Buonaiuto,V, Ruiz-Moreno,MI, López-Carmona,MD, Pérez-Belmonte,LM, Gómez-Huelgas,R, Bernal-López,MR] Internal Medicine Department, Regional University Hospital of Málaga, Instituto de Investigación Biomédica de Málaga (IBIMA), Malaga, Spain. [Gómez-Huelgas,R, Bernal-López,MR] Ciber Fisiopatología de la Obesidad y Nutrición. Instituto de Salud Carlos III, Madrid, Spain., This work was supported by grants from the Instituto de Salud Carlos III, cofinancial by the Fondo Europeo de Desarrollo Regional-FEDER (PI12/01373 and 'Centros de Investigación En Red' (CIBER, CB06/03/0018)), and from the Consejería de Economía, Innovación, Ciencia y Empleo-FEDER (P07-CTS 656 and CTS-1023, Junta de Andalucía, Spain). María Rosa Bernal-Lopez was supported by 'Miguel Servet Type I' program (CP15/00028) from the ISCIII-Madrid (Spain), cofinanced by the Fondo Europeo de Desarrollo Regional-FEDER.
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Male
Phenomena and Processes::Genetic Phenomena::Phenotype [Medical Subject Headings]
Health
Toxicology and Mutagenesis

lcsh:Medicine
Type 2 diabetes
Overweight
Índice de masa corporal
Analytical
Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Probability::Risk::Risk Factors [Medical Subject Headings]

Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings]
0302 clinical medicine
Liver Function Tests
Risk Factors
Liver function tests
Body mass index
education.field_of_study
medicine.diagnostic_test
diabetes
Fatty liver
Diabetes
Enfermedad del hígado graso no alcohólico
Lipids
Analytical
Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cross-Sectional Studies [Medical Subject Headings]

Phenotype
Lípidos
Diseases::Nutritional and Metabolic Diseases::Metabolic Diseases::Glucose Metabolism Disorders::Diabetes Mellitus::Diabetes Mellitus
Type 2 [Medical Subject Headings]

030211 gastroenterology & hepatology
Female
medicine.symptom
Analytical
Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Diagnostic Techniques
Digestive System::Liver Function Tests [Medical Subject Headings]

Adult
medicine.medical_specialty
Analytical
Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Anthropometry::Body Weights and Measures::Body Mass Index [Medical Subject Headings]

Population
Check Tags::Male [Medical Subject Headings]
030209 endocrinology & metabolism
body mass index
Article
lipids
Diseases::Nutritional and Metabolic Diseases::Metabolic Diseases::Glucose Metabolism Disorders::Diabetes Mellitus::Prediabetic State [Medical Subject Headings]
03 medical and health sciences
Diseases::Cardiovascular Diseases::Vascular Diseases::Hypertension [Medical Subject Headings]
Internal medicine
Diabetes mellitus
Analytical
Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Physical Examination::Body Constitution::Body Weights and Measures::Body Size::Body Weight::Overweight [Medical Subject Headings]

medicine
Humans
education
Persons::Persons::Age Groups::Adult [Medical Subject Headings]
Geographical Locations::Geographic Locations::Europe::Spain [Medical Subject Headings]
business.industry
Hypertriglyceridemia
fungi
lcsh:R
Public Health
Environmental and Occupational Health

Analytical
Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Area Under Curve [Medical Subject Headings]

Andalucía
Pruebas de función hepática
medicine.disease
Diseases::Nutritional and Metabolic Diseases::Metabolic Diseases::Lipid Metabolism Disorders::Dyslipidemias::Hyperlipidemias::Hypercholesterolemia [Medical Subject Headings]
Endocrinology
Cross-Sectional Studies
Diabetes Mellitus
Type 2

Andalusian
Check Tags::Female [Medical Subject Headings]
Spain
business
Non-alcoholic fatty liver disease
Zdroj: International Journal of Environmental Research and Public Health, Vol 17, Iss 3518, p 3518 (2020)
International Journal of Environmental Research and Public Health
Volume 17
Issue 10
Popis: The aim of this study was to analyze the utility of liver function tests (LFT) and fatty liver index (FLI), a surrogate marker of non-alcoholic fatty liver disease, in the categorization of metabolic phenotypes in a Mediterranean population. A cross-sectional study was performed on a random representative sample of 2233 adults assigned to a health center in Má
laga, Spain. The metabolic phenotypes were determined based on body mass index (BMI) categorization and the presence or absence of two or more cardiometabolic abnormalities (high blood pressure, low high-density lipoprotein (HDL) cholesterol, hypertriglyceridemia, pre-diabetes) or type 2 diabetes. No difference was observed between metabolically healthy and metabolically abnormal phenotypes on LFT. The mean FLI of the population was 41.1 ±
28.6. FLI was significantly higher (p <
0.001) in the metabolically abnormal phenotypes in all BMI categories. The proportion of individuals with pathological FLI (&ge
60) was significantly higher in the metabolically abnormal overweight and obese phenotypes (p <
0.001). On a multivariate model adjusted for sex, age, and waist circumference, a significant correlation was found between pathological FLI and metabolically abnormal phenotypes in the overweight and obese BMI categories. Area under the curve (AUC) of FLI as a biomarker was 0.76, 0.74, and 0.72 for the metabolically abnormal normal-weight, overweight, and obese groups, respectively. Liver biochemistry is poorly correlated with metabolic phenotypes. Conversely, a good correlation between FLI, as a marker of non-alcoholic fatty liver disease (NAFLD), and metabolically abnormal phenotypes in all BMI ranges was found. Our study suggests that FLI may be a useful marker for characterizing metabolically abnormal phenotypes in individuals who are overweight or obese.
Databáze: OpenAIRE