USP12 positively regulates M‐MDSC function to inhibit antitumour immunity through deubiquitinating and stabilizing p65

Autor: Xiaoxia Zhan, Qiuying He, Junli Sheng, Xiaobing Jiang, Letao Lin, Yulan Huang, Shitong He, Yitian Chen, Laisheng Li, Zhijie Zeng, Shengfeng Hu, Peng Wang, Yanling Zhang
Rok vydání: 2022
Předmět:
Zdroj: Immunology. 167:544-557
ISSN: 1365-2567
0019-2805
DOI: 10.1111/imm.13552
Popis: The relative abundance of myeloid-derived suppressor cells (MDSCs) compared to cytotoxic T cells determines the outcomes of diseases and the efficacy of immunotherapy. Ubiquitin-specific peptidase 12 (USP12), a member of the USP family of deubiquitinases, targets multiple signalling pathways and regulates diverse biological processes, including cell proliferation and survival. It is well known that ubiquitylation is an important mechanism for regulating the immune response. However, it is unclear whether USP12 regulates tumour growth by influencing MDSCs. In the present study, we reported that USP12 deficiency decreased infiltration and impaired the suppressor function of monocytic (M)-MDSCs, resulting in increased CD8
Databáze: OpenAIRE
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