Marine Invertebrate Natural Products that Target Microtubules
| Autor: | A. Jonathan Singh, Jeremy G. Owen, Jessica J. Field, Arun Kanakkanthara, Peter T. Northcote, John H. Miller |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Aquatic Organisms Pharmaceutical Science Biology Microtubules 01 natural sciences Natural (archaeology) Analytical Chemistry 03 medical and health sciences Microtubule Drug Discovery Animals Humans Symbiosis Pharmacology Biological Products Bacteria 010405 organic chemistry Organic Chemistry Marine invertebrates biology.organism_classification Invertebrates 0104 chemical sciences 030104 developmental biology Complementary and alternative medicine Biochemistry Molecular Medicine Eukaryote |
| Zdroj: | Journal of Natural Products. 81:691-702 |
| ISSN: | 1520-6025 0163-3864 |
| DOI: | 10.1021/acs.jnatprod.7b00964 |
| Popis: | Marine natural products as secondary metabolites are a potential major source of new drugs for treating disease. In some cases, cytotoxic marine metabolites target the microtubules of the eukaryote cytoskeleton for reasons that will be discussed. This review covers the microtubule-targeting agents reported from sponges, corals, tunicates, and molluscs and the evidence that many of these secondary metabolites are produced by bacterial symbionts. The review finishes by discussing the directions for future development and production of clinically relevant amounts of these natural products and their analogues through aquaculture, chemical synthesis, and biosynthesis by bacterial symbionts. |
| Databáze: | OpenAIRE |
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