Working memory in the odor span task: effects of chlordiazepoxide, dizocilpine (MK801), morphine, and scopolamine
| Autor: | Andrew Hawkey, L. Brooke April, Melissa Deal, Mark Galizio |
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| Rok vydání: | 2012 |
| Předmět: |
Male
Agonist medicine.drug_class Scopolamine Receptors N-Methyl-D-Aspartate Cholinergic Antagonists Article Chlordiazepoxide Discrimination Learning Rats Sprague-Dawley medicine Animals GABA Modulators Pharmacology Benzodiazepine Dose-Response Relationship Drug Morphine Working memory fungi Olfactory Perception Rats Analgesics Opioid Dizocilpine Memory Short-Term NMDA receptor Dizocilpine Maleate Opiate Psychology Excitatory Amino Acid Antagonists Neuroscience medicine.drug |
| Zdroj: | Psychopharmacology. |
| ISSN: | 1432-2072 0033-3158 |
| Popis: | A number of tasks are used to assess working memory in rodents, but the odor span task (OST) is unique in studying performance as a function of the number of stimuli to remember. The purpose of the present study was to better characterize the behavioral pharmacology of the OST by exploring the effects of several amnestic agents including an NMDA antagonist (dizocilpine), a positive GABA-A modulator (chlordiazepoxide), an anticholinergic compound (scopolamine), and as a negative control, an opiate receptor agonist (morphine). Rats were trained to perform on the OST which is a non-match-to-sample procedure with an incrementing number of sample odors to remember as the session progresses. Trials with a simple odor discrimination task (SD) were interspersed to provide a control for effects unrelated to memory load. All four drugs disrupted performances on the OST task in a dose-dependent fashion, but only the NMDA antagonist dizocilpine produced impairments that were clearly dependent on the number of stimuli to remember. Dizocilpine impaired OST performance at a dose (0.1 mg/kg) that did not affect SD, and that impairment depended on memory load. Chlordiazepoxide (3.0 mg/kg) also produced amnestic effects that were manifest by shorter memory spans and runs of correct responding. In contrast, morphine and scopolamine impaired OST accuracy only at doses that also disrupted SD (18.0 and 0.3 mg/kg, respectively). These results provide evidence of NMDA and benzodiazepine modulation of working memory as assessed by the OST. |
| Databáze: | OpenAIRE |
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