Anti-obesity effect of cocoa proteins (Theobroma cacao L.) variety 'Criollo' and the expression of genes related to the dysfunction of white adipose tissue in high-fat diet-induced obese rats
| Autor: | Luis Mojica, Griselda Rabadán-Chávez, Angel Miliar Garcia, Luis Jorge Coronado-Cáceres, Blanca Hernández-Ledesma, Lucía Quevedo-Corona, Eugenia Lugo-Cervantes |
|---|---|
| Přispěvatelé: | Consejo Nacional de Ciencia y Tecnología (México), Instituto Politécnico Nacional (México), Ministerio de Economía y Competitividad (España) |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Functional foods medicine.medical_treatment Adipose tissue Medicine (miscellaneous) White adipose tissue Biology 03 medical and health sciences 0404 agricultural biotechnology Internal medicine Gene expression medicine TX341-641 Obesity 030109 nutrition & dietetics Nutrition and Dietetics Nutrition. Foods and food supply Insulin Leptin food and beverages AMPK 04 agricultural and veterinary sciences medicine.disease 040401 food science Endocrinology Lipogenesis Food protein lipids (amino acids peptides and proteins) Anti-inflammatory hormones hormone substitutes and hormone antagonists Food Science |
| Zdroj: | Journal of Functional Foods, Vol 62, Iss, Pp-(2019) Digital.CSIC. Repositorio Institucional del CSIC instname |
| ISSN: | 1756-4646 |
| DOI: | 10.1016/j.jff.2019.103519 |
| Popis: | The objective of this work was to evaluate if Cocoa Proteins (CP) from the cocoa-bean were able to reduce factors related to obesity and activated related gene targets against white adipose tissue (WAT) dysfunction in a rat model of hypercaloric diet-induced obesity. The results showed that the administration with 150 mg/kg/day of CP on a hypercaloric diet reduces body-weight gain, relative weight of WAT, serum triglycerides, NEFAs, insulin, and leptin levels, and pro-inflammatory factors, with an increase in serum HDL levels, activation (AMPK, PPAR-γ, PPAR-α, SIRT1, Plin1, and PGC-1α) and repression (TNF-α, SREBP-1c, Leptin and ACC) of the mRNA of transcription factors and proteins related to WAT dysfunction. The CP prevented dysfunction in WAT who is related to obesity by down-regulation of factors related to lipogenesis and up-regulation of those related to energy expenditure, lowering the release of triglycerides and NEFAs into peripheral tissues, thus decreasing pro-inflammatory processes. This study was funded by projects 2017-02-291417 “Development of technological innovations for the sustainable integral management of the cocoa crop (Theobroma cacao L.) in Mexico” (CONACYT-SAGARPA), AGL2015-66886-R (Ministry of Science, Innovation, and Universities, Spain) and SIP20180524 (Instituto Politécnico Nacional, IPN). |
| Databáze: | OpenAIRE |
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