Serum Bilirubin Level is Negatively Correlated With Disease Progression of Peripheral Arterial Disease
| Autor: | Bing Liu, Wei-Hui Zhang, Peng Han, Hai-jun Wang, Haiyang Wang, Hali Li, Ren-ping Huang |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Adult
medicine.medical_specialty Bilirubin Arterial disease Observation Gastroenterology Cohort Studies Peripheral Arterial Disease Young Adult chemistry.chemical_compound Risk Factors Internal medicine medicine Humans Young adult Risk factor Aged Aged 80 and over business.industry Disease progression Middle Aged Atherosclerosis Surgery Peripheral Blood pressure chemistry Disease Progression Regression Analysis Female Cardiology and Cardiovascular Medicine business Cohort study |
| Zdroj: | Angiology. 63:248-253 |
| ISSN: | 1940-1574 0003-3197 |
| DOI: | 10.1177/0003319711425175 |
| Popis: | We determined whether low bilirubin level is a risk factor for peripheral arterial disease (PAD). We recruited 318 patients with PAD and 100 healthy volunteers. Patients were divided into 4 groups by the Fontaine classification for PAD, namely, group 1 (grade 1, n = 4); group 2 (grade 2, n = 114), group 3 (grade 3, n = 164), and group 4 (grade 4, n = 36). Total bilirubin (T-BIL), direct bilirubin (D-BIL), and indirect bilirubin (I-BIL) levels were compared using stepwise multiple regressions adjusted for selected factors. After adjusting for gender, age, smoking, and diastolic blood pressure, serum levels of T-BIL, D-BIL, and I-BIL were significantly lower in the PAD group ( P < .05). Patients with grade 4 PAD showed significantly ( P < .05) lower levels of T-BIL when compared with grade 2 patients. We concluded that serum bilirubin levels are negatively correlated with the severity and progression of PAD. |
| Databáze: | OpenAIRE |
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