Location, location: using functional magnetic resonance imaging to pinpoint brain differences relevant to stimulant use
| Autor: | Jennifer L. Aron, Martin P. Paulus |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Male
Cingulate cortex Amphetamine-Related Disorders Medicine (miscellaneous) Methamphetamine Cocaine-Related Disorders Neuroimaging Functional neuroimaging medicine Humans Prefrontal cortex Brain Diseases medicine.diagnostic_test Brain Magnetic Resonance Imaging Functional imaging Dorsolateral prefrontal cortex Psychiatry and Mental health medicine.anatomical_structure Posterior cingulate Central Nervous System Stimulants Female Cognition Disorders Psychology Functional magnetic resonance imaging Neuroscience |
| Zdroj: | Addiction. 102:33-43 |
| ISSN: | 1360-0443 0965-2140 |
| DOI: | 10.1111/j.1360-0443.2006.01778.x |
| Popis: | Aims The purpose of this review is to summarize the neural substrate dysfunctions and disrupted cognitive, affective andexperientialprocessesobservedinmethamphetamineandcocaine-dependentindividuals.Methods Wereviewed all publications in PubMed that conducted comparison studies between healthy volunteers and cocaine-, amphetamine- or methamphetamine-dependent individuals using functional magnetic resonance imaging. Results Stimulant dependence is characterized by a distributed alteration of functional activation to a number of experimental paradigms. Attenuated anterior and posterior cingulate activation, reduced inferior frontal and dorsolateral prefrontal cortex activation and altered posterior parietal activation point towards an inadequate demand-specific processing of information. Processes reported most consistently to be deficient in these functional neuroimaging studies include inhibitory control, executive functioning and decision-making. Conclusion One emerging theme is that stimulantdependent individuals show specific, rather than generic, brain activation differences, i.e. instead of showing more or lessbrainactivationregardlessof task,theyexhibitprocess-relatedbrainactivationdifferencesthatareconsistentwith a shift from context-specific, effortful processing to more stereotyped, habitual response generation. |
| Databáze: | OpenAIRE |
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