Neopterin as a marker of cellular immunological response
Autor: | Piotr Szcześniak, Magdalena Bulska, Łukasz Michalak, Karolina Strząbała |
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Jazyk: | angličtina |
Rok vydání: | 2017 |
Předmět: |
0301 basic medicine
Microbiology (medical) medicine.medical_specialty Modern medicine monocyty lcsh:Medicine Neopterin Virus Autoimmune Diseases Pathogenesis 03 medical and health sciences chemistry.chemical_compound neopteryna 0302 clinical medicine Immune system Immunity immune system diseases Internal medicine medicine Humans Interferon gamma 030212 general & internal medicine odporność immunologiczna typu komórkowego Immunity Cellular business.industry pterydyna lcsh:R Dendritic Cells Rheumatology 030104 developmental biology Infectious Diseases chemistry Immunology nowotwory business Biomarkers medicine.drug makrofagi |
Zdroj: | Postępy Higieny i Medycyny Doświadczalnej, Vol 71, Iss 1, Pp 727-736 (2017) |
ISSN: | 1732-2693 0032-5449 |
Popis: | Neopterin is a pyrazino-pyrimidine compound that belongs to the pteridine group. It is known to be a biochemical marker associated with cell-mediated immunity. It is produced by human monocytes/macrophages and dendritic cells from guanosine triphosphate (GTP) upon stimulation with interferon gamma (IFNγ), which is released by activated limphocytes Th. Neopterin is a very important clinic parameter, though the physiological role has not been exactly definited thus far. The level of neopterin reflects the stage of activation of the cellular immune system, which is important in the pathogenesis and progression of various diseases. Measuring its concentration in body fluids is used in many different areas of modern medicine, such as infectious disease, gastroenterology, transplantology and transfusiology, rheumatology or oncology. In neurological, cardio-vascular and autoimmune diseases, cell-mediated immunity is also activated, which is proved by the elevated level of this marker. Measurements of neopterin concentrations are also helpful in monitoring the therapy of patients infected with the HIV virus or treated by using immunomudulating therapy. As a result of measuring levels of neopterin in patients with neoplasms of digestive tract, increased concentration was proved, but it is not routinely used in everyday clinic practice. |
Databáze: | OpenAIRE |
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