Association of Epstein-Barr virus infection with oral squamous cell carcinoma in a case-control study
| Autor: | Kulchaya Loyha, Tipaya Ekalaksananan, Patravoot Vatanasapt, Supannee Promthet, Pensiri Phusingha, Bunkerd Kongyingyoes, Sulav Acharya, Chamsai Pientong |
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| Rok vydání: | 2014 |
| Předmět: |
Male
Epstein-Barr Virus Infections Herpesvirus 4 Human Cancer Research Alcohol Drinking medicine.disease_cause Polymerase Chain Reaction Virus Pathology and Forensic Medicine law.invention Lesion Risk Factors law hemic and lymphatic diseases Odds Ratio Prevalence medicine Humans Risk factor Epstein–Barr virus infection Areca Polymerase chain reaction Aged Squamous Cell Carcinoma of Head and Neck business.industry Smoking Case-control study Middle Aged Thailand medicine.disease Epstein–Barr virus stomatognathic diseases Otorhinolaryngology Head and Neck Neoplasms Case-Control Studies DNA Viral Immunology Carcinoma Squamous Cell Periodontics Female Mouth Neoplasms Oral Surgery medicine.symptom business Nested polymerase chain reaction |
| Zdroj: | Journal of Oral Pathology & Medicine. 44:252-257 |
| ISSN: | 0904-2512 |
| Popis: | Background Besides the well-known risk factors, Epstein-Barr virus (EBV) might play a significant role in oral squamous cell carcinoma (OSCC). To explore the role of EBV in OSCC, the prevalence of EBV infection in oral exfoliated cells of OSCC cases and controls in northeastern Thailand was investigated, and the association of EBV in tumor lesion cells was further confirmed. Methods Oral exfoliated cells were collected from OSCC cases and non-cancer controls. Cells from tumor lesions were taken from OSCC patients for further strong confirmation of the association of EBV with OSCC. EBV DNA was detected by polymerase chain reaction (PCR) using primers specific for EBV DNA polymerase. The EBV DNA positive samples were confirmed further by nested PCR. Results Epstein-Barr virus was detected in the oral exfoliated cells of 45.05% of OSCC patients and 18.08% of the non-cancer control (P |
| Databáze: | OpenAIRE |
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