The association between thoracic sarcopenia and survival is gender specific in early-stage lung cancer
| Autor: | Connor J, Wakefield, Nicholas, Lund, Julia, Coughlin, Justin M, Karush, Nicole, Geissen, Gillian, Alex, Michael J, Liptay, Jeffrey A, Borgia, Palmi, Shah, Christopher W, Seder |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Journal of Thoracic Disease. 14:4256-4265 |
| ISSN: | 2077-6624 2072-1439 |
| DOI: | 10.21037/jtd-22-273 |
| Popis: | Sarcopenia, as measured at the 3rd lumbar (L3) level, has been shown to prognosticate survival in cancer patients. However, many patients with early-stage non-small cell lung cancer (NSCLC) do not undergo abdominal imaging. We hypothesized that preoperative thoracic sarcopenia is associated with survival in patients undergoing lung resection for early-stage NSCLC.Patients who underwent anatomic resection for NSCLC between 2010-2019 were retrospectively identified. Exclusion criteria included induction therapy, less than 90 days of follow-up, and absence of computed tomography (CT) imaging. Cross sectional skeletal muscle area was calculated at the fifth thoracic vertebra (T5), twelfth thoracic vertebra (T12), and L3 level. Gender-specific lowest quartile values and previously defined values were used to define sarcopenia. Overall survival and disease-free survival were assessed using the Kaplan-Meier method.Overall, 221 patients met inclusion criteria with a median body mass index (BMI) of 26.5 kg/mSarcopenia at T5 is associated with worse survival in males, but not females. When using upper thoracic vertebral levels to assess for sarcopenia, it is necessary to account for gender. |
| Databáze: | OpenAIRE |
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