The effect of lutein- and zeaxanthin-rich foods v. supplements on macular pigment level and serological markers of endothelial activation, inflammation and oxidation: pilot studies in healthy volunteers
| Autor: | Ryan Graydon, Ian S. Young, Ruth E Hogg, Usha Chakravarthy, Jayne V. Woodside |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Adult
Male Risk Lutein medicine.medical_specialty Endothelium medicine.medical_treatment Medicine (miscellaneous) Pilot Projects Inflammation Northern Ireland Xanthophylls Biology Placebo medicine.disease_cause Antioxidants Retina Endothelial activation Macular Degeneration Young Adult chemistry.chemical_compound Double-Blind Method Functional Food Zeaxanthins Internal medicine medicine Humans Nutrition and Dietetics Carotene food and beverages Middle Aged eye diseases Intention to Treat Analysis Zeaxanthin Oxidative Stress medicine.anatomical_structure Endocrinology chemistry Biochemistry Dietary Supplements Female Endothelium Vascular medicine.symptom Retinal Pigments Biomarkers Oxidative stress |
| Zdroj: | British Journal of Nutrition. 108:334-342 |
| ISSN: | 1475-2662 0007-1145 |
| DOI: | 10.1017/s0007114511005599 |
| Popis: | The aim of the present study was to compare the effect of lutein- and zeaxanthin-rich foods and supplements on macular pigment level (MPL) and serological markers of endothelial activation, inflammation and oxidation in healthy volunteers. We conducted two 8-week intervention studies. Study 1 (n 52) subjects were randomised to receive either carrot juice (a carotene-rich food) or spinach powder (a lutein- and zeaxanthin-rich food) for 8 weeks. Study 2 subjects (n 75) received supplements containing lutein and zeaxanthin, β-carotene, or placebo for 8 weeks in a randomised, double-blind, placebo-controlled trial. MPL, serum concentrations of lipid-soluble antioxidants, inter-cellular adhesion molecule 1, vascular cell adhesion molecule 1, C-reactive protein and F2-isoprostane levels were assessed at baseline and post-intervention in both studies. In these intervention studies, no effects on MPL or markers of endothelial activation, inflammation or oxidation were observed. However, the change in serum lutein and zeaxanthin was associated or tended to be associated with the change in MPL in those receiving lutein- and zeaxanthin-rich foods (lutein r 0·40, P = 0·05; zeaxanthin r 0·30, P = 0·14) or the lutein and zeaxanthin supplement (lutein r 0·43, P = 0·03; zeaxanthin r 0·22, P = 0·28). In both studies, the change in MPL was associated with baseline MPL (food study r − 0·54, P r − 0·40, P |
| Databáze: | OpenAIRE |
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