Factors associated with melanoma-related limb lymphoedema

Autor:	Caroline A. Gjorup, Lisbet Rosenkrantz Hölmich, Krzysztof T. Drzewiecki, Tobias Wirenfeldt Klausen, Karin Dahlstroem, Helle W. Hendel
Rok vydání:	2021
Předmět:	medicine.medical_specialty Skin Neoplasms 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Biopsy Humans Medicine Radiology Nuclear Medicine and imaging In patient Lymphedema Melanoma Lymph node medicine.diagnostic_test Sentinel Lymph Node Biopsy business.industry Late effect Hematology General Medicine Sentinel node medicine.disease body regions Dissection Cross-Sectional Studies medicine.anatomical_structure Oncology Lymphatic Metastasis 030220 oncology & carcinogenesis Lymph Node Excision Radiology medicine.symptom business
Zdroj:	Acta Oncologica. 60:779-784
ISSN:	1651-226X 0284-186X
Popis:	Melanoma-related limb lymphoedema is a well-known late effect following sentinel node biopsy (SNB), and lymph node dissection (LND) in patients treated of melanoma. However, data on associated risk factors are sparse. This study aimed to investigate factors associated with melanoma-related limb lymphoedema.The present cross-sectional single-center clinical study included patients between 18 and 75 years with American Joint Committee on Cancer Stages I-III melanoma treated with wide local excision (WLE) and unilateral axillary or inguinal SNB and/or completion LND (CLND) or therapeutic LND (TLND). The diagnosis of secondary unilateral limb lymphoedema was based on the history, symptoms, and physical examination and staged according to the International Society of Lymphology (ISL). Data on factors associated with lymphoedema were analysed with binary logistic regression models.In total, 642 patients were eligible, of which 435 (68%) patients participated in the study. Among these 431 patients, 109 (25%) had lymphoedema of which 48 (44%), and 61 (56%) were classified with ISL Stages I and II-III, respectively. Multivariate analyses identified primary tumour on the limb (odds ratio [OR], 2.28; 95% confidence interval [CI], 1.17-4.56;Melanoma-related limb lymphoedema is associated with inguinal surgery, LND, primary tumour on the limb, persistent pain at the site of lymph node surgery, and cellulitis of the limb. This study highlights the importance of increasing awareness, improving prevention, and treatment of melanoma-related limb lymphoedema.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51bd7a8b187b0713b218c70e0e7c91f3 https://doi.org/10.1080/0284186x.2021.1905175 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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