Gene probe analysis demonstrates independent clonal evolution of co-existent chronic myeloid and chronic lymphocytic leukaemia
| Autor: | P. J. Browett, J Pattinson, John D. Norton, A. V. Hoffbrand, Jonathan Pinkney |
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| Rok vydání: | 2009 |
| Předmět: |
Male
Immunoglobulin gene Myeloid Chromosomes Human Pair 22 Chronic lymphocytic leukemia Population Immunoglobulins Biology Somatic evolution in cancer Translocation Genetic hemic and lymphatic diseases medicine Humans Philadelphia Chromosome education Aged Recombination Genetic education.field_of_study breakpoint cluster region Hematology General Medicine Gene rearrangement medicine.disease Leukemia Lymphoid medicine.anatomical_structure Genes Genetic Techniques Leukemia Myeloid Cancer research Immunoglobulin heavy chain |
| Zdroj: | European Journal of Haematology. 40:181-184 |
| ISSN: | 1600-0609 0902-4441 |
| Popis: | We describe a case of Philadelphia-positive chronic myeloid leukaemia occurring simultaneously with B-cell chronic lymphocytic leukaemia in a 69-yr-old male. Gene probe analysis of DNA from both peripheral blood and bone marrow provided evidence for the independent evolution of 2 clones in this case, with a predominant population showing immunoglobulin heavy chain gene rearrangement and a smaller population showing a rearrangement within the breakpoint cluster region of chromosome 22. |
| Databáze: | OpenAIRE |
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