Detection of serum MCP-1 and TGF-β1 in polymyositis/dermatomyositis patients and its significance
| Autor: | Li-Hua Zhang, Li Li, Chun-Ye Wu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty lcsh:Medicine 030204 cardiovascular system & hematology PM/DM Gastroenterology Polymyositis behavioral disciplines and activities Dermatomyositis Pathogenesis Transforming Growth Factor beta1 03 medical and health sciences 0302 clinical medicine Internal medicine TGF-β1 medicine Humans 030212 general & internal medicine Chemokine CCL2 business.industry Monocyte Research lcsh:R Interstitial lung disease General Medicine respiratory system medicine.disease respiratory tract diseases body regions Polymyositis-Dermatomyositis medicine.anatomical_structure Female Complication business ILD Transforming growth factor MCP-1 |
| Zdroj: | European Journal of Medical Research European Journal of Medical Research, Vol 24, Iss 1, Pp 1-5 (2019) |
| ISSN: | 2047-783X 0949-2321 |
| Popis: | Objective This study aims to detect serum levels of monocyte chemoattractant protein-1 (MPC-1) and transforming growth factor-β1 (TGF-β1) in polymyositis/dermatomyositis (PM/DM) patients complicated with interstitial lung disease (ILD), to reveal the significance of the changes in these levels in the pathogenesis of PM/DM complicated with ILD. Methods Serum MCP-1 and TGF-β1 levels in PM/DM patients complicated with ILD, patients with pulmonary infections and normal controls (n = 30, each) were detected using enzyme-linked immunosorbent assay (ELISA), and the correlation between PM/DM complicated with ILD and serum MCP-1 and TGF-β1 levels was analyzed. Results Serum MCP-1 and TGF-β1 levels were both higher in PM/DM patients complicated with ILD compared with patients with pulmonary infections and normal controls. Conclusion Serum MCP-1 and TGF-β1 levels increased in PM/DM patients, and were closely correlated to the complication of ILD. This finding can be used for distinguishing between pulmonary infections and ILD, providing a new diagnostic method for the early prediction of DM/PM complicated with ILD. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink