SIRT1 gene variants are related to risk of childhood obesity
| Autor: | Ufuk Erenberk, Birsen Elibol-Can, Omer Uysal, Ozlem Gok, İlker Tolga Özgen, Ulkan Kilic, Mehmet Rusen Dundaroz |
|---|---|
| Přispěvatelé: | ERENBERK, UFUK |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Male
Pediatric Obesity medicine.medical_specialty Childhood Obesity Genotype Turkey medicine.medical_treatment SNP Blood Pressure Polymerase Chain Reaction Childhood obesity Body Mass Index chemistry.chemical_compound SIRT1 Kilic U. GOK O. ELIBOL-CAN B. Ozgen I. T. Erenberk U. Uysal O. DUNDAROZ M. R. -SIRT1 gene variants are related to risk of childhood obesity- EUROPEAN JOURNAL OF PEDIATRICS cilt.174 ss.473-479 2015 Gene Frequency Sirtuin 1 Risk Factors Polymorphism (computer science) Internal medicine medicine Humans Insulin Genetic Predisposition to Disease Allele Child Alleles PCR-CTPP Polymorphism Genetic Adiponectin Triglyceride business.industry Epigenetic medicine.disease Lipids Obesity Endocrinology chemistry Pediatrics Perinatology and Child Health Female business |
| Popis: | WOS: 000351515300008 PubMed ID: 25233986 Obesity is a multifactorial disorder resulting from the interaction between genetic, psychological, physical, environmental, and socioeconomic factors. SIRT1 gene has important effects on the regulation of adiponectin, caloric restriction, insulin sensitivity, coronary atherosclerosis, and cardiovascular diseases. The aim of this study was to investigate the association between childhood obesity and SIRT1 gene polymorphisms regarding rs7895833 A > G in the promoter region, rs7069102 C > G in intron 4, and rs2273773 C > T in exon 5 using PCR-CTPP method in 120 obese and 120 normal weight children. In this study, BMI, systolic and diastolic blood pressure, LDL cholesterol, triglyceride, and insulin levels were significantly higher and HDL-cholesterol levels were significantly lower in obese children compared to normal weight children. For rs7895833 A > G, the rate of having AG genotype and G allele was significantly higher in obese children compared to non-obese group (p < 0.001). The risk for obesity was increased by 1.9 times in G allele carriers; therefore, A allele may be protective against obesity. Both study groups had CT heterozygote genotype for rs2273773 C > T. There was no significant difference for rs7069102 C > G gene polymorphism between groups. Conclusion: This is the first study reporting an association between SIRT1 gene polymorphisms and obesity in children. University Research Council, Bezmialem Vakif University [BAP: 9.2012/15] This study was supported by grants from the University Research Council, Bezmialem Vakif University (BAP: 9.2012/15). The authors would like to thank Assoc. Prof. Dr. Arzu Ergen for her help in this study. |
| Databáze: | OpenAIRE |
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