Growth and endocrine function after treatment for medulloblastoma
| Autor: | D C Savage, T J Lee, J A Bullimore, I H Brown, O B Eden |
|---|---|
| Rok vydání: | 1983 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty Adolescent Growth Craniospinal Irradiation Growth hormone deficiency Follicle-stimulating hormone Thyroid-stimulating hormone Endocrine Glands Internal medicine medicine Humans Endocrine system Euthyroid Cerebellar Neoplasms Child Medulloblastoma business.industry Puberty medicine.disease Combined Modality Therapy Body Height Endocrinology Child Preschool Growth Hormone Pediatrics Perinatology and Child Health Female Follicle Stimulating Hormone business Follow-Up Studies Research Article Endocrine gland |
| Zdroj: | Archives of Disease in Childhood. 58:722-727 |
| ISSN: | 1468-2044 0003-9888 |
| DOI: | 10.1136/adc.58.9.722 |
| Popis: | Children with medulloblastoma in Bristol are treated surgically and with craniospinal irradiation, and in some cases chemotherapy. Thirteen medium or long term survivors were investigated to determine their growth and endocrine function. Their rate of growth was considerably reduced through the first year of their illness and after spinal irradiation spinal growth was poor. Nine children developed growth hormone deficiency. They were clinically euthyroid but 7 had raised basal thyroid stimulating hormone values. Gonadal function was abnormal in all but the youngest child. The rate of survival is increasing in children with medulloblastoma but this is associated with appreciable endocrine abnormalities. Some of these problems are present shortly after treatment ends but others may develop later and long term surveillance is therefore essential. |
| Databáze: | OpenAIRE |
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