Cytochrome c enhancement of singlet molecular oxygen production by the NADPH-dependent adrenodoxin reductase-adrenodoxin system: The role of singlet oxygen in damaging adrenal mitochondrial membranes
| Autor: | Kiyoshi Goda, Tokuji Kimura, A. Paul Schaap, Jau-wen Chu |
|---|---|
| Rok vydání: | 1973 |
| Předmět: |
Xanthine Oxidase
Chemical Phenomena Free Radicals Biophysics Cytochrome c Group Biochemistry Adrenodoxin reductase Superoxide dismutase chemistry.chemical_compound Adrenodoxin Adrenal Glands Animals NADH NADPH Oxidoreductases Molecular Biology Octane Aldehydes biology Superoxide Dismutase Singlet oxygen Cytochrome c Cell Biology Catalase Malondialdehyde Lipids Enzyme Activation Oxygen Chemistry Kinetics chemistry Luminescent Measurements biology.protein Ferredoxins Cattle Dismutase Oxidoreductases NADP |
| Zdroj: | Biochemical and Biophysical Research Communications. 52:1300-1306 |
| ISSN: | 0006-291X |
| DOI: | 10.1016/0006-291x(73)90642-6 |
| Popis: | In the presence of NADPH, cytochrome c stimulates approximately a 200-fold increase in the production of singlet oxygen by the bovine adrenodoxin reductase-adrenodoxin system. The formation of singlet oxygen, which was monitored by the attending chemiluminescence, was markedly inhibited by the addition of superoxide dismutase or 1,4-diazabicyclo[2.2.2]octane. The adrenal system, in the presence of cytochrome c, peroxidized adrenal mitochondrial lipids, as indicated by the formation of malondialdehyde. This oxidation is also inhibited by the addition of dismutase and 1,4-diazabicyclo[2.2.2]octane. |
| Databáze: | OpenAIRE |
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