Improving clinical paediatric research and learning from COVID-19: recommendations by the Conect4Children expert advice group

Autor: Ramanan, Athimalaipet V., Modi, Neena, de Wildt, Saskia N., Aurich, Beate, Bakhtadze, Sophia, Sirvent, Francisco J. Bautista, Cabañas, Fernando, Campbell, Lisa, Casanova, Michaela, Charlton, Philippa, Crandall, Wallace, Eichler, Irmgard, Fregonese, Laura, Hawcutt, Daniel B., Iveli, Pablo, Jaki, Thomas, Jocic-Jakubi, Bosanka, Johnson, Mats, Kaguelidou, Florentina, Karadag, Bülent, Kelly, Lauren E., Lim, Ming, Moreno, Carmen, Neumann, Eva, Ollivier, Cécile, Oualha, Mehdi, Raffaeli, Genny, Ribeiro, Maria A., Roilides, Emmanuel, de Rojas, Teresa, Simón, Alba Rubio San, Ruperto, Nicolino, Scarpa, Maurizio, Schwab, Matthias, Siapkara, Angeliki, Singh, Yogen, Smits, Anne, Striano, Pasquale, Urru, Silvana A. M., Vivarelli, Marina, de Wildt, Saskia, Zivkoviz, Zorica
Přispěvatelé: Pediatric Surgery, Ramanan A. V. , Modi N., de Wildt S. N. , Aurich B., Bakhtadze S., Sirvent F. J. B. , Cabañas F., Campbell L., Casanova M., Charlton P., et al.
Jazyk: angličtina
Rok vydání: 2021
Předmět:
2019-20 coronavirus outbreak
Coronavirus disease 2019 (COVID-19)
Expert advice
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
MEDLINE
Sağlık Bilimleri
Pediatrics
Clinical Medicine (MED)
Çocuk Sağlığı ve Hastalıkları
Child Health and Diseases
Special Article
03 medical and health sciences
0302 clinical medicine
Health Sciences
Health care
Humans
Klinik Tıp (MED)
030212 general & internal medicine
Pediatrics
Perinatology
and Child Health
Pediatri
Perinatoloji ve Çocuk Sağlığı
Child
Pandemics
Internal Medicine Sciences
Klinik Tıp
business.industry
Research
COVID-19
Dahili Tıp Bilimleri
CLINICAL MEDICINE
Public relations
Tıp
3. Good health
Europe
Clinical research
030220 oncology & carcinogenesis
Pediatrics
Perinatology and Child Health
Medicine
PEDİATRİ
Renal disorders Radboud Institute for Health Sciences [Radboudumc 11]
business
Zdroj: Pediatric Research
Pediatric research
Pediatric Research, 91, 1069-1077
Pediatric Research, 91, 5, pp. 1069-1077
CORE (RIOXX-UK Aggregator)
PubMed Central
ORCID
Microsoft Academic Graph
OpenAIRE
Pediatric Research, 91(5), 1069-1077. Lippincott Williams & Wilkins
ISSN: 1530-0447
0031-3998
DOI: 10.1038/s41390-021-01587-3
Popis: Background The COVID-19 pandemic has had a devastating impact on multiple aspects of healthcare, but has also triggered new ways of working, stimulated novel approaches in clinical research and reinforced the value of previous innovations. Conect4children (c4c, www.conect4children.org) is a large collaborative European network to facilitate the development of new medicines for paediatric populations, and is made up of 35 academic and 10 industry partners from 20 European countries, more than 50 third parties, and around 500 affiliated partners. Methods We summarise aspects of clinical research in paediatrics stimulated and reinforced by COVID-19 that the Conect4children group recommends regulators, sponsors, and investigators retain for the future, to enhance the efficiency, reduce the cost and burden of medicines and non-interventional studies, and deliver research-equity. Findings We summarise aspects of clinical research in paediatrics stimulated and reinforced by COVID-19 that the Conect4children group recommends regulators, sponsors, and investigators retain for the future, to enhance the efficiency, reduce the cost and burden of medicines and non-interventional studies, and deliver research-equityWe provide examples of research innovation, and follow this with recommendations to improve the efficiency of future trials, drawing on industry perspectives, regulatory considerations, infrastructure requirements and parent–patient–public involvement. We end with a comment on progress made towards greater international harmonisation of paediatric research and how lessons learned from COVID-19 studies might assist in further improvements in this important area.
Databáze: OpenAIRE
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