Regulation of leucocyte homeostasis in the circulation
| Autor: | Andrés Hidalgo, Paul S. Frenette, Christoph Scheiermann |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Physiology
Lymphocyte Cell Biology ddc:616.07 Cholesterol/metabolism Immune system Cell Movement Physiology (medical) medicine Leukocytes Animals Homeostasis Humans Platelet Hemostatic function Leukocytes/physiology Cell biology Invited Spotlight Reviews Haematopoiesis medicine.anatomical_structure Cholesterol Immunology Blood Circulation Bone marrow Cardiology and Cardiovascular Medicine |
| Zdroj: | Cardiovascular Research, Vol. 107, No 3 (2015) pp. 340-51 |
| ISSN: | 0008-6363 |
| Popis: | The functions of blood cells extend well beyond the immune functions of leucocytes or the respiratory and hemostatic functions of erythrocytes and platelets. Seen as a whole, the bloodstream is in charge of nurturing and protecting all organs by carrying a mixture of cell populations in transit from one organ to another. To optimize these functions, evolution has provided blood and the vascular system that carries it with various mechanisms that ensure the appropriate influx and egress of cells into and from the circulation where and when needed. How this homeostatic control of blood is achieved has been the object of study for over a century, and although the major mechanisms that govern it are now fairly well understood, several new concepts and mediators have recently emerged that emphasize the dynamism of this liquid tissue. Here we review old and new concepts that relate to the maintenance and regulation of leucocyte homeostasis in blood and briefly discuss the mechanisms for platelets and red blood cells. |
| Databáze: | OpenAIRE |
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