Changes in isovolumic segment shortening following acute coronary occlusion: disproportionate effects of anterior versus posterior ischemia
| Autor: | Etsuro Araie, Akira Ohno, Dean Franklin, Kazuto Yamanishi, Masatoshi Fujita, Shigetake Sasayama, Daniel P. McKown |
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| Rok vydání: | 1989 |
| Předmět: |
medicine.medical_specialty
Heart Ventricles Ischemia Hemodynamics Coronary Disease Anterior Descending Coronary Artery Dogs Heart Rate Internal medicine medicine Carnivora Animals Isovolumetric contraction biology business.industry Fissipedia Stroke Volume medicine.disease biology.organism_classification Coronary Vessels Myocardial Contraction Coronary occlusion Ventricular pressure Cardiology Cardiology and Cardiovascular Medicine business |
| Zdroj: | International journal of cardiology. 22(1) |
| ISSN: | 0167-5273 |
| Popis: | We evaluated the changes in left ventricular pressure and isovolumic segment shortening in both the ischemic and nonischemic areas following acute coronary occlusion in 12 conscious dogs instrumented for the measurement of subendocardial segment lengths perfused by the left circumflex coronary artery and left anterior descending coronary artery, and left ventricular pressure. An externally inflatable pneumatic occluder was placed around the left circumflex coronary artery. In 6 dogs, another occluder was installed around the proximal left anterior descending coronary artery. Under the resting conditions, the isovolumic segment shortening in the areas supplied by the left anterior descending coronary artery and the left circumflex coronary artery were 2.1 +/- 0.5% (SE) and -0.1 +/- 0.5% (P less than 0.01; versus values in the area of the left anterior descending coronary artery), respectively. During a 1-min occlusion of the left circumflex coronary artery, the isovolumic shortening in the anterior segment increased to 3.8 +/- 0.5% (P less than 0.001; versus values in the basal state), while the posterior segment produced isovolumic elongation (-2.2 +/- 0.5%, P less than 0.001; versus values in the basal state). By contrast, during a 1-min occlusion of the left anterior descending coronary artery, the extent of isovolumic bulge in the anterior segment and the augmentation in the isovolumic shortening in the posterior segment was less prominent compared with the occlusion of the left circumflex coronary artery.(ABSTRACT TRUNCATED AT 250 WORDS) |
| Databáze: | OpenAIRE |
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