A ruthenium(II) complex with the propionate ion: Synthesis, characterization and cytotoxic activity

Autor:	Pollyanna Francielli de Oliveira, Thalita M.P. Pagoto, Marcos Pivatto, Gustavo Von Poelhsitz, Elisangela de Paula Silveira-Lacerda, Larissa L.G. Sobrinho, Adriana P. M. Guedes, Victor M. Deflon, Denise Crispim Tavares, Murilo C. Carroccia, Angelica E. Graminha, Alzir A. Batista
Rok vydání:	2015
Předmět:	chemistry.chemical_classification Denticity Chemistry Stereochemistry Ligand General Chemical Engineering chemistry.chemical_element Biological activity General Chemistry RUTÊNIO Ruthenium chemistry.chemical_compound X-ray crystallography Propionate Carboxylate Cytotoxicity
Zdroj:	Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP
ISSN:	1631-0748
DOI:	10.1016/j.crci.2015.07.008
Popis:	The complex [Ru(η 2 -O 2 CCH 2 CH 3 )(dppe) 2 ]PF 6 (dppe = 1,2-bis(diphenylphosphino)ethane) was prepared and characterized by elemental analysis, spectroscopic techniques, X-ray crystallography, HRESIMS and HRESIMS/MS. The characterization data are consistent with a cis arrangement for the dppe ligands and a bidentate coordination of the propionate ligand through carboxylate oxygens. Cytotoxicity assays were carried out on human and murine cancer and normal cell lines. In general, the [Ru(η 2 -O 2 CCH 2 CH 3 )(dppe) 2 ]PF 6 complex was more cytotoxic than both its precursor cis –[RuCl 2 (dppe) 2 ] and the reference metallodrug cisplatin. The best results against the HepG2 human tumour cell line and S180 murine tumour cell line were found with IC 50 values of 6.5 ± 0.2 and 0.18 ± 0.03 μM, respectively.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51b4b4ddc4122efc63bb8acec96e09bc https://doi.org/10.1016/j.crci.2015.07.008 Zobrazit plný text záznamu